PMID- 24222646
OWN - NLM
STAT- MEDLINE
DCOM- 20140611
LR  - 20220409
IS  - 1424-3997 (Electronic)
IS  - 0036-7672 (Linking)
VI  - 143
DP  - 2013
TI  - Breaking and building the wall: the biology of the blood-brain barrier in health 
      and disease.
PG  - w13892
LID - 10.4414/smw.2013.13892 [doi]
AB  - The blood-brain barrier (BBB) is a complex feature of brain endothelial cells 
      that restricts the passage of blood-borne molecules into the brain parenchyma, 
      while ensuring the delivery of essential nutrients and selected biomolecules. 
      Brain vasculature is anatomically distinct from that of other organs and 
      comprises in addition to endothelial cells, pericytes and astrocytes, which 
      collectively form the neurovascular unit (NVU). This review focuses on the 
      regulation of BBB properties by the NVU and the periphery. A brief overview of 
      cellular components of the NVU, and BBB characteristics will be provided, with 
      more emphasis placed on the molecular mechanisms involved in the development of 
      brain vasculature and human genetic diseases primarily affected by dysfunction of 
      components of the NVU. In addition, the regulation of brain vasculature by 
      peripheral factors such as diet and systemic disease is discussed.
FAU - Keller, Annika
AU  - Keller A
AD  - Institute of Neuropathology, Schemlzbergstrasse 12, ZA(1/4)rich, SWITZERLAND; 
      Annika.Keller@usz.ch.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20131112
PL  - Switzerland
TA  - Swiss Med Wkly
JT  - Swiss medical weekly
JID - 100970884
SB  - IM
MH  - Astrocytes/*physiology
MH  - Blood-Brain Barrier/*physiology/physiopathology
MH  - Brain/*blood supply
MH  - Endothelium, Vascular/*physiology/physiopathology
MH  - Humans
MH  - Intercellular Junctions/physiology
MH  - Pericytes/*physiology
EDAT- 2013/11/14 06:00
MHDA- 2014/06/12 06:00
CRDT- 2013/11/14 06:00
PHST- 2013/11/14 06:00 [entrez]
PHST- 2013/11/14 06:00 [pubmed]
PHST- 2014/06/12 06:00 [medline]
AID - smw-13892 [pii]
AID - 10.4414/smw.2013.13892 [doi]
PST - epublish
SO  - Swiss Med Wkly. 2013 Nov 12;143:w13892. doi: 10.4414/smw.2013.13892. eCollection 
      2013.