PMID- 24223626
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 6
IP  - 5
DP  - 2013 Nov
TI  - Characteristics of gastrointestinal symptoms and function following endoscopic 
      submucosal dissection and treatment of the gastrointestinal symptoms using 
      rikkunshito.
PG  - 1083-1088
AB  - The aim of the present study was to investigate the gastrointestinal (GI) 
      symptoms and gastric emptying following endoscopic submucosal dissection (ESD), 
      as well as to evaluate a novel treatment strategy using rikkunshito, a 
      traditional Japanese herbal medicine. GI symptoms and gastric emptying were 
      evaluated 6-8 days after ESD as part of the Step I study. In the Step 1 study, 
      the Gastrointestinal Symptom Rating Scale (GSRS) scores of the two groups after 4 
      and 8 weeks of treatment with either a proton pump inhibitor (PPI; PPI 
      monotreatment group, n=5) or a PPI plus rikkunshito (PPI + rikkunshito group, 
      n=8) were compared against baseline values. Abdominal pain and constipation 
      occurred in the majority of patients after ESD. The mean T-max 6-8 days after 
      gastric emptying was 75.4+/-13.6 min, which was significantly longer compared with 
      that reported in healthy subjects (43.9+/-10.3 min). In the Step 2 study, the total 
      GSRS score was significantly improved only in the PPI + rikkunshito group after 8 
      weeks of treatment. In conclusion, ESD affects gastric emptying and is associated 
      with an increased incidence of upper GI symptoms such as abdominal pain and 
      indigestion. Rikkunshito may be useful as a novel supporting therapeutic drug for 
      the treatment of GI symptoms in patients who have undergone ESD.
FAU - Uehara, Ryohei
AU  - Uehara R
AD  - Department of Gastroenterology and Hepatology, Nagasaki University Graduate 
      School of Biomedical Sciences, Nagasaki 852-8501, Japan.
FAU - Isomoto, Hajime
AU  - Isomoto H
FAU - Minami, Hitomi
AU  - Minami H
FAU - Yamaguchi, Naoyuki
AU  - Yamaguchi N
FAU - Ohnita, Ken
AU  - Ohnita K
FAU - Ichikawa, Tatsuki
AU  - Ichikawa T
FAU - Takeshima, Fuminao
AU  - Takeshima F
FAU - Shikuwa, Saburo
AU  - Shikuwa S
FAU - Nakao, Kazuhiko
AU  - Nakao K
LA  - eng
PT  - Journal Article
DEP - 20130913
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC3820687
OTO - NOTNLM
OT  - abdominal pain
OT  - endoscopic submucosal dissection
OT  - gastric cancer
OT  - gastric emptying
OT  - rikkunshito
EDAT- 2013/11/14 06:00
MHDA- 2013/11/14 06:01
PMCR- 2013/09/13
CRDT- 2013/11/14 06:00
PHST- 2013/04/20 00:00 [received]
PHST- 2013/08/07 00:00 [accepted]
PHST- 2013/11/14 06:00 [entrez]
PHST- 2013/11/14 06:00 [pubmed]
PHST- 2013/11/14 06:01 [medline]
PHST- 2013/09/13 00:00 [pmc-release]
AID - etm-06-05-1083 [pii]
AID - 10.3892/etm.2013.1299 [doi]
PST - ppublish
SO  - Exp Ther Med. 2013 Nov;6(5):1083-1088. doi: 10.3892/etm.2013.1299. Epub 2013 Sep 
      13.