PMID- 24223667
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 6
IP  - 5
DP  - 2013 Nov
TI  - Serum erythropoietin level predicts the prognosis of chronic heart failure with 
      or without anemia.
PG  - 1327-1331
AB  - The aim of this study was to explore the correlation of erythropoietin (EPO) with 
      N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high sensitivity 
      C-reactive protein (hs-CRP) in patients with chronic heart failure (CHF) or CHF 
      complicated with anemia, in addition to its correlation with the prognosis of the 
      patient. A total of 217 CHF patients were enrolled in this study. The patients 
      were graded according to the cardiac function criteria of the New York Heart 
      Association (NYHA). The serum EPO, NT-proBNP and hs-CRP levels of the patients 
      were determined. The patients were followed up for >/=24 months. The EPO expression 
      level in patients with NYHA II-IV CHF was significantly higher compared with that 
      in the control group (P<0.05). EPO expression increased with the aggravation of 
      CHF, exhibiting significant differences amongst the various NYHA graded groups 
      (P<0.05). The EPO expression level increased significantly with an increase in 
      NHA grade in addition to the severity of the anemia in the patients with CHF 
      complicated by anemia (P<0.05). In the patients who succumbed (mortality group), 
      the expression level of EPO was significantly higher and the hemoglobin level was 
      significantly lower compared with those of the survival group (P<0.05). The EPO 
      expression levels were elevated in CHF patients and patients with CHF and anemia. 
      The level of expression correlated positively with the severity of CHF as well as 
      that of anemia. Serum EPO measurements were successful in predicting the 
      mortality and re-hospitalization rates of CHF patients at the end point, within 
      two years of follow-up.
FAU - Guo, Ling
AU  - Guo L
AD  - Departments of Cardiology, Provincial Hospital Affiliated to Shandong University, 
      Jinan, Shandong 250021, P.R China.
FAU - Wang, Ai-Hong
AU  - Wang AH
FAU - Sun, Yong-LE
AU  - Sun YL
FAU - Lv, Lin
AU  - Lv L
FAU - Xu, Chong-En
AU  - Xu CE
LA  - eng
PT  - Journal Article
DEP - 20130918
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC3820832
OTO - NOTNLM
OT  - N-terminal pro-B-type natriuretic peptide
OT  - erythropoietin
OT  - heart failure
OT  - high sensitivity C-reactive protein
OT  - prognosis
EDAT- 2013/11/14 06:00
MHDA- 2013/11/14 06:01
PMCR- 2013/09/18
CRDT- 2013/11/14 06:00
PHST- 2013/05/15 00:00 [received]
PHST- 2013/09/02 00:00 [accepted]
PHST- 2013/11/14 06:00 [entrez]
PHST- 2013/11/14 06:00 [pubmed]
PHST- 2013/11/14 06:01 [medline]
PHST- 2013/09/18 00:00 [pmc-release]
AID - etm-06-05-1327 [pii]
AID - 10.3892/etm.2013.1307 [doi]
PST - ppublish
SO  - Exp Ther Med. 2013 Nov;6(5):1327-1331. doi: 10.3892/etm.2013.1307. Epub 2013 Sep 
      18.