PMID- 24224849
OWN - NLM
STAT- MEDLINE
DCOM- 20141210
LR  - 20240322
IS  - 1751-7893 (Electronic)
IS  - 1751-7885 (Print)
IS  - 1751-7885 (Linking)
VI  - 8
IP  - 2
DP  - 2014 May
TI  - Substance use in clinical high risk for psychosis: a review of the literature.
PG  - 104-12
LID - 10.1111/eip.12100 [doi]
AB  - AIM: In the literature, there is evidence suggesting an association between 
      substance use and psychosis. However, little is known about substance use in 
      those who may be in the pre-psychotic phase, that is, those who are putatively 
      prodromal are considered to be at clinical high risk (CHR) of developing 
      psychosis. METHODS: We conducted a review of publications measuring patterns and 
      rates of substance use in CHR for psychosis individuals and the effects on the 
      transition to psychosis. RESULTS: Of 5527 potentially relevant research papers, 
      10 met inclusion criteria of CHR subjects and specifically mentioned substance 
      use in the sample. The results of these studies varied. Cannabis, alcohol and 
      tobacco/nicotine were reported as the most commonly used substances. There was 
      limited information on the changes in patterns of use over time. Two out of the 
      ten studies found a significant association between the use of substances and 
      subsequent transition to psychosis. In one of these studies, substance abuse was 
      a predictor of psychosis when included as a variable in a prediction algorithm. 
      In the other study, the abuse of cannabis and nicotine was associated with 
      transition to psychosis. CONCLUSIONS: We found limited evidence to suggest that 
      increased rates of substance use may be associated with transition to psychosis. 
      However, further prospective research examining the association between substance 
      use and transition to psychosis is required before any firm conclusions can be 
      made.
CI  - (c) 2013 Wiley Publishing Asia Pty Ltd.
FAU - Addington, Jean
AU  - Addington J
AD  - Hotchkiss Brain Institute, Department of Psychiatry, University of Calgary, 
      Calgary, Alberta, Canada.
FAU - Case, Nevicia
AU  - Case N
FAU - Saleem, Majid M
AU  - Saleem MM
FAU - Auther, Andrea M
AU  - Auther AM
FAU - Cornblatt, Barbara A
AU  - Cornblatt BA
FAU - Cadenhead, Kristin S
AU  - Cadenhead KS
LA  - eng
GR  - U01 MH081984/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20131114
PL  - Australia
TA  - Early Interv Psychiatry
JT  - Early intervention in psychiatry
JID - 101320027
SB  - IM
MH  - Drug Users/*psychology
MH  - Humans
MH  - Prevalence
MH  - Prodromal Symptoms
MH  - Psychotic Disorders/*complications/epidemiology/*psychology
MH  - Substance-Related Disorders/*complications/epidemiology/*psychology
PMC - PMC4356483
MID - NIHMS606169
OTO - NOTNLM
OT  - cannabis
OT  - clinical high risk
OT  - psychosis
OT  - review
OT  - substance use
EDAT- 2013/11/15 06:00
MHDA- 2014/12/15 06:00
PMCR- 2015/03/11
CRDT- 2013/11/15 06:00
PHST- 2013/04/01 00:00 [received]
PHST- 2013/09/22 00:00 [accepted]
PHST- 2013/11/15 06:00 [entrez]
PHST- 2013/11/15 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
PHST- 2015/03/11 00:00 [pmc-release]
AID - 10.1111/eip.12100 [doi]
PST - ppublish
SO  - Early Interv Psychiatry. 2014 May;8(2):104-12. doi: 10.1111/eip.12100. Epub 2013 
      Nov 14.