PMID- 24225051
OWN - NLM
STAT- MEDLINE
DCOM- 20140724
LR  - 20211021
IS  - 1477-7525 (Electronic)
IS  - 1477-7525 (Linking)
VI  - 11
DP  - 2013 Nov 13
TI  - Evaluation of health related quality of life in children with immune 
      thrombocytopenia with the PedsQL 4.0 Generic Core Scales: a study on behalf of 
      the pays de Loire pediatric hematology network.
PG  - 193
LID - 10.1186/1477-7525-11-193 [doi]
AB  - BACKGROUND: Immune thrombocytopenia (ITP) is a childhood disorder that is often 
      life-altering for children and their parents. Health related quality of life 
      (HRQL) has never been chronologically monitored in children with ITP. We 
      initiated a prospective study to assess HRQL from diagnosis to six months and 
      define factors that influence this outcome in children with ITP. METHODS: 73 
      children with acute ITP aged from 2 to 18 years were prospectively enrolled in 
      the study. According to the presence of bleeding, they were or were not given a 
      4-day course of corticosteroid treatment. The PedsQL 4.0 Generic Core Scale was 
      completed by children and parents upon their inclusion in the study and 6 months 
      after diagnosis. RESULTS: Over the six month period, quality of life improved in 
      terms of their global, physical and psychosocial well-being for 54.5%, 35.6% and 
      36.2% of patients respectively. This improvement is clinically relevant compared 
      to scores at diagnosis, corresponding at least to a minimal clinically important 
      difference (MCID). Factors such as sex, age, platelet count, bleeding scores, 
      bone marrow aspiration and persistence of ITP at 6 months were not significantly 
      associated with HRQL scores. However, preceding viral infection was identified to 
      have an impact on HRQL. CONCLUSIONS: This first longitudinal study assessing HRQL 
      in children with ITP reveals a global improvement in PedSQL 4.0. However, these 
      results should be considered with caution since our data also confirm that 
      self-report HRQL scores are not influenced by any analyzed biologic or clinical 
      parameters. Others tools, such as Kids' ITP Tools, would probably be required to 
      assess the HRQL of this population. TRIAL REGISTRATION: Trial registration 
      clinical trials.gov Identifier: NCT00331357.
FAU - Strullu, Marion
AU  - Strullu M
FAU - Rakotonjanahary, Josue
AU  - Rakotonjanahary J
FAU - Tarral, Eliane
AU  - Tarral E
FAU - Savagner, Christophe
AU  - Savagner C
FAU - Thomas, Caroline
AU  - Thomas C
FAU - Mechinaud, Francoise
AU  - Mechinaud F
FAU - Reguerre, Yves
AU  - Reguerre Y
FAU - Poignant, Sylvaine
AU  - Poignant S
FAU - Boutet, Arnaud
AU  - Boutet A
FAU - Bassil, Joachim
AU  - Bassil J
FAU - Medinger, Dominique
AU  - Medinger D
FAU - Quemener, Emmanuel
AU  - Quemener E
FAU - Young, Nancy L
AU  - Young NL
FAU - Rachieru, Petronela
AU  - Rachieru P
FAU - Klaassen, Robert J
AU  - Klaassen RJ
FAU - Pellier, Isabelle
AU  - Pellier I
AD  - Service d'Immuno-Hemato-Oncologie Pediatrique, CHU d'Angers, 4 rue Larrey, 49933 
      Angers, Cedex 09, France, UE. IsPellier@chu-angers.fr.
LA  - eng
SI  - ClinicalTrials.gov/NCT00331357
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131113
PL  - England
TA  - Health Qual Life Outcomes
JT  - Health and quality of life outcomes
JID - 101153626
SB  - IM
MH  - Adolescent
MH  - Autoimmune Diseases/psychology
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - France
MH  - *Health Status
MH  - Humans
MH  - Male
MH  - Prospective Studies
MH  - Quality of Life/*psychology
MH  - Surveys and Questionnaires/*standards
MH  - Thrombocytopenia/*immunology/*psychology
PMC - PMC3830442
EDAT- 2013/11/15 06:00
MHDA- 2014/07/25 06:00
PMCR- 2013/11/13
CRDT- 2013/11/15 06:00
PHST- 2013/05/21 00:00 [received]
PHST- 2013/10/17 00:00 [accepted]
PHST- 2013/11/15 06:00 [entrez]
PHST- 2013/11/15 06:00 [pubmed]
PHST- 2014/07/25 06:00 [medline]
PHST- 2013/11/13 00:00 [pmc-release]
AID - 1477-7525-11-193 [pii]
AID - 10.1186/1477-7525-11-193 [doi]
PST - epublish
SO  - Health Qual Life Outcomes. 2013 Nov 13;11:193. doi: 10.1186/1477-7525-11-193.