PMID- 24225238
OWN - NLM
STAT- MEDLINE
DCOM- 20141113
LR  - 20220311
IS  - 0253-3758 (Print)
IS  - 0253-3758 (Linking)
VI  - 41
IP  - 8
DP  - 2013 Aug
TI  - [Effects of cardiac resynchronization therapy in patients with advanced 
      congestive heart failure evaluated by real-time 3-dimensional echocardiography].
PG  - 668-73
AB  - OBJECTIVE: To quantitatively assess the effects of cardiac resynchronization 
      therapy (CRT) in patients with advanced congestive heart failure by real-time 
      3-dimensional(3D) echocardiography (RT-3DE). METHODS: Eighteen patients with 
      advanced congestive heart failure underwent CRT with New York Heart 
      association(NYHA) class III and IV and wide QRS complex (>120 ms) were included 
      (17 dilated cardiomyopathy and 1 ischemic cardiomyopathy). Before CRT and 8 
      months after CRT, the clinical and RT-3DE parameters and outcome were analyzed. 
      RESULTS: The biventricular pacemaker was successfully implanted in 17 patients 
      (94.4%). Compared with before CRT, NYHA class of patients decreased by 1.5 class 
      (P < 0.01), left ventricular ejection fraction increased by 25% (P < 0.01), left 
      ventricular end systolic volume decreased by 38% (P < 0.01), left ventricular 
      systolic dyssynchrony index (SDI) improved significantly (14.2% before CRT vs. 
      9.8% after CRT, P < 0.01 ) post CRT. Change in SDI and change in LVEF was 
      positively correlated (r = 0.62, P < 0.01) . The procedure complications and 
      outcome during and after CRT included coronary sinus dissection (n = 1), left 
      ventricular lead dislodgement (n = 1), phrenic nerve stimulation (n = 1), sudden 
      cardiac death (n = 1). Three non-response patients were complicated with atrial 
      fibrillation, nonspecific intraventricular block and dilated cardiomyopathy with 
      postero-lateral scar tissue. CONCLUSIONS: CRT could improve the cardiac function, 
      correct the mechanical desynchronization and reverse left ventricular remodeling 
      in patients with congestive heart failure, and SDI quantification by RT-3DE could 
      predict increase of LVEF after CRT, however, there were complications related to 
      the implantation procedure and possibilities of non-response.
FAU - Zhao, Yong-hui
AU  - Zhao YH
AD  - Department of Cardiology, Henan Provincial People's Hospital, Zhengzhou 450003, 
      China.
FAU - Zhang, Jia-ying
AU  - Zhang JY
FAU - Wei, Chang-hua
AU  - Wei CH
FAU - Wang, Xian-qing
AU  - Wang XQ
FAU - Zhang, Jing
AU  - Zhang J
FAU - Xu, Yu
AU  - Xu Y
FAU - Gao, Chuan-yu
AU  - Gao CY
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Xin Xue Guan Bing Za Zhi
JT  - Zhonghua xin xue guan bing za zhi
JID - 7910682
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cardiac Pacing, Artificial/methods
MH  - *Cardiac Resynchronization Therapy
MH  - *Echocardiography, Three-Dimensional
MH  - Female
MH  - Heart Failure/*therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Treatment Outcome
EDAT- 2013/11/15 06:00
MHDA- 2014/11/14 06:00
CRDT- 2013/11/15 06:00
PHST- 2013/11/15 06:00 [entrez]
PHST- 2013/11/15 06:00 [pubmed]
PHST- 2014/11/14 06:00 [medline]
PST - ppublish
SO  - Zhonghua Xin Xue Guan Bing Za Zhi. 2013 Aug;41(8):668-73.