PMID- 24227797
OWN - NLM
STAT- MEDLINE
DCOM- 20141020
LR  - 20160511
IS  - 2042-6984 (Electronic)
IS  - 2042-6976 (Linking)
VI  - 4
IP  - 1
DP  - 2014 Jan
TI  - The significance of serum total immunoglobulin E for in vitro diagnosis of 
      allergic rhinitis.
PG  - 56-60
LID - 10.1002/alr.21240 [doi]
AB  - BACKGROUND: Allergic rhinitis is diagnosed by clinical parameters with no widely 
      accepted screening test. Measurement of total serum immunoglobulin E (IgE) has 
      limited use in the general population due to a low negative predictive value. The 
      value of total IgE level in select populations undergoing in vitro allergy 
      testing remains unknown. The aim of this study is to determine the utility of 
      total serum IgE in the in vitro diagnosis of allergic rhinitis. METHODS: A 
      retrospective chart review of patients undergoing testing for allergic rhinitis 
      was performed. Clinical parameters, total IgE level, and enzyme-linked 
      immunosorbent assay (ELISA) for serum-specific IgE levels were analyzed with 
      multivariate logistic regression. The positive and negative predictive values and 
      a receiver operating characteristic (ROC) curve were used to assess the utility 
      of total IgE in predicting serum-specific IgE test results. RESULTS: Records from 
      1073 patients were reviewed. ROC curve for total IgE >150 IU/mL (Sigma 0.88) 
      indicates good discrimination in identifying patients with sensitization by in 
      vitro testing, whereas low total IgE level had strong negative predictive value 
      (0.87, IgE <10) in identifying negative specific IgE testing. Multivariate 
      logistic regression showed that differences in covariables did not significantly 
      change the odds of a positive in vitro allergy test panel. CONCLUSION: Serum 
      total IgE level is useful in the in vitro diagnosis of allergic rhinitis. In 
      vitro testing for specific IgE may be unnecessary in patients with low serum 
      total IgE, whereas high total IgE level suggests that in vitro testing would 
      confirm specific sensitizations in patients with allergic rhinitis.
CI  - (c) 2013 ARS-AAOA, LLC.
FAU - Chung, Daniel
AU  - Chung D
AD  - Department of Otolaryngology-Head & Neck Surgery, Boston University School of 
      Medicine, Boston, MA.
FAU - Park, K T
AU  - Park KT
FAU - Yarlagadda, Bharat
AU  - Yarlagadda B
FAU - Davis, Elizabeth Mahoney
AU  - Davis EM
FAU - Platt, Michael
AU  - Platt M
LA  - eng
PT  - Journal Article
DEP - 20131112
PL  - United States
TA  - Int Forum Allergy Rhinol
JT  - International forum of allergy & rhinology
JID - 101550261
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Child
MH  - Child, Preschool
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Infant
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Rhinitis, Allergic, Perennial/blood/*diagnosis
MH  - Sensitivity and Specificity
MH  - Young Adult
OTO - NOTNLM
OT  - allergic rhinitis
OT  - allergy
OT  - atopy
OT  - immunoglobulin E
OT  - in vitro testing
EDAT- 2013/11/15 06:00
MHDA- 2014/10/21 06:00
CRDT- 2013/11/15 06:00
PHST- 2013/08/11 00:00 [received]
PHST- 2013/09/17 00:00 [accepted]
PHST- 2013/11/15 06:00 [entrez]
PHST- 2013/11/15 06:00 [pubmed]
PHST- 2014/10/21 06:00 [medline]
AID - 10.1002/alr.21240 [doi]
PST - ppublish
SO  - Int Forum Allergy Rhinol. 2014 Jan;4(1):56-60. doi: 10.1002/alr.21240. Epub 2013 
      Nov 12.