PMID- 24227939
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131114
LR  - 20211021
IS  - 1226-4512 (Print)
IS  - 2093-3827 (Electronic)
IS  - 1226-4512 (Linking)
VI  - 17
IP  - 5
DP  - 2013 Oct
TI  - Chronic administration of baicalein decreases depression-like behavior induced by 
      repeated restraint stress in rats.
PG  - 393-403
LID - 10.4196/kjpp.2013.17.5.393 [doi]
AB  - Baicalein (BA), a plant-derived active flavonoid present in the root of 
      Scutellaria baicalensis, has been widely used for the treatment of stress-related 
      neuropsychiatric disorders including depression. Previous studies have 
      demonstrated that repeated restraint stress disrupts the activity of the 
      hypothalamic-pituitary-adrenal (HPA) axis, resulting in depression. The 
      behavioral and neurochemical basis of the BA effect on depression remain unclear. 
      The present study used the forced swimming test (FST) and changes in brain 
      neurotransmitter levels to confirm the impact of BA on repeated restraint 
      stress-induced behavioral and neurochemical changes in rats. Male rats received 
      10, 20, or 40 mg/kg BA (i.p.) 30 min prior to daily exposure to repeated 
      restraint stress (2 h/day) for 14 days. Activation of the HPA axis in response to 
      repeated restraint stress was confirmed by measuring serum corticosterone levels 
      and the expression of corticotrophin-releasing factor in the hypothalamus. Daily 
      BA administration significantly decreased the duration of immobility in the FST, 
      increased sucrose consumption, and restored the stress-related decreases in 
      dopamine concentrations in the hippocampus to near normal levels. BA 
      significantly inhibited the stress-induced decrease in neuronal tyrosine 
      hydroxylase immunoreactivity in the ventral tegmental area and the expression of 
      brain-derived neurotrophic factor (BDNF) mRNA in the hippocampus. Taken together, 
      these findings indicate that administration of BA prior to the repeated restraint 
      stress significantly improves helpless behaviors and depressive symptoms, 
      possibly by preventing the decrease in dopamine and BDNF expression. Thus, BA may 
      be a useful agent for the treatment or alleviation of the complex symptoms 
      associated with depression.
FAU - Lee, Bombi
AU  - Lee B
AD  - Acupuncture and Meridian Science Research Center, College of Oriental Medicine, 
      Kyung Hee University, Seoul 130-701, Korea.
FAU - Sur, Bongjun
AU  - Sur B
FAU - Park, Jinhee
AU  - Park J
FAU - Kim, Sung-Hun
AU  - Kim SH
FAU - Kwon, Sunoh
AU  - Kwon S
FAU - Yeom, Mijung
AU  - Yeom M
FAU - Shim, Insop
AU  - Shim I
FAU - Lee, Hyejung
AU  - Lee H
FAU - Hahm, Dae-Hyun
AU  - Hahm DH
LA  - eng
PT  - Journal Article
DEP - 20131017
PL  - Korea (South)
TA  - Korean J Physiol Pharmacol
JT  - The Korean journal of physiology & pharmacology : official journal of the Korean 
      Physiological Society and the Korean Society of Pharmacology
JID - 9709505
PMC - PMC3823951
OTO - NOTNLM
OT  - Baicalein
OT  - Chronic stress
OT  - Depression
OT  - Dopamine
OT  - Hypothalamus-pituitary-adrenal axis
EDAT- 2013/11/15 06:00
MHDA- 2013/11/15 06:01
PMCR- 2013/10/01
CRDT- 2013/11/15 06:00
PHST- 2013/04/23 00:00 [received]
PHST- 2013/07/12 00:00 [revised]
PHST- 2013/08/06 00:00 [accepted]
PHST- 2013/11/15 06:00 [entrez]
PHST- 2013/11/15 06:00 [pubmed]
PHST- 2013/11/15 06:01 [medline]
PHST- 2013/10/01 00:00 [pmc-release]
AID - 10.4196/kjpp.2013.17.5.393 [doi]
PST - ppublish
SO  - Korean J Physiol Pharmacol. 2013 Oct;17(5):393-403. doi: 
      10.4196/kjpp.2013.17.5.393. Epub 2013 Oct 17.