PMID- 24228179
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140624
LR  - 20211021
IS  - 2090-3014 (Print)
IS  - 2090-3022 (Electronic)
IS  - 2090-3022 (Linking)
VI  - 2013
DP  - 2013
TI  - Targeting antigens to dendritic cell receptors for vaccine development.
PG  - 869718
LID - 10.1155/2013/869718 [doi]
LID - 869718
AB  - Dendritic cells (DCs) are highly specialized antigen presenting cells of the 
      immune system which play a key role in regulating immune responses. Depending on 
      the method of antigen delivery, DCs stimulate immune responses or induce 
      tolerance. As a consequence of the dual function of DCs, DCs are studied in the 
      context of immunotherapy for both cancer and autoimmune diseases. In vaccine 
      development, a major aim is to induce strong, specific T-cell responses. This is 
      achieved by targeting antigen to cell surface molecules on DCs that efficiently 
      channel the antigen into endocytic compartments for loading onto MHC molecules 
      and stimulation of T-cell responses. The most attractive cell surface receptors, 
      expressed on DCs used as targets for antigen delivery for cancer and other 
      diseases, are discussed.
FAU - Apostolopoulos, Vasso
AU  - Apostolopoulos V
AD  - VA Consulting Services, Melbourne, VIC, Australia ; College of Health and 
      Biomedicine, Victoria University, VIC, Australia.
FAU - Thalhammer, Theresia
AU  - Thalhammer T
FAU - Tzakos, Andreas G
AU  - Tzakos AG
FAU - Stojanovska, Lily
AU  - Stojanovska L
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20131008
PL  - Egypt
TA  - J Drug Deliv
JT  - Journal of drug delivery
JID - 101553818
PMC - PMC3817681
EDAT- 2013/11/15 06:00
MHDA- 2013/11/15 06:01
PMCR- 2013/10/08
CRDT- 2013/11/15 06:00
PHST- 2012/12/12 00:00 [received]
PHST- 2013/07/11 00:00 [accepted]
PHST- 2013/11/15 06:00 [entrez]
PHST- 2013/11/15 06:00 [pubmed]
PHST- 2013/11/15 06:01 [medline]
PHST- 2013/10/08 00:00 [pmc-release]
AID - 10.1155/2013/869718 [doi]
PST - ppublish
SO  - J Drug Deliv. 2013;2013:869718. doi: 10.1155/2013/869718. Epub 2013 Oct 8.