PMID- 24228829
OWN - NLM
STAT- MEDLINE
DCOM- 20150112
LR  - 20140508
IS  - 1563-5279 (Electronic)
IS  - 0020-7454 (Linking)
VI  - 124
IP  - 6
DP  - 2014 Jun
TI  - Prognostic factors and health-related quality of life in ocular Myasthenia Gravis 
      (OMG).
PG  - 427-35
LID - 10.3109/00207454.2013.853664 [doi]
AB  - We evaluate the factors predictive of prognosis in 91 Caucasian patients affected 
      by ocular myasthenia gravis (OMG), followed at our Institution during an 
      observational time, ranging from 12 to 240 months. The Myasthenia Gravis 
      Foundation of America (MGFA) clinical classification was used to grade the 
      disease severity. We considered as outcome measures the variation in two 
      subscores, ocular (O-QMG) and nonocular (NO-QMG); the last one reflected bulbar, 
      neck, extremity functions. None of the independent variables evaluated for 
      association with the outcome, as age of onset, type of therapy, length of 
      interval between first and last examinations, and presence of antibodies to 
      acetylcholine receptors (AChR-Abs) significantly affected the evolution of O-QMG 
      and of NO-QMG. Health-related quality of life (HRQol) was assessed in 63 
      patients. Variations of diplopia or ptosis did not affect significantly physical 
      (PCS) or mental composite subscores (MCS) of the Short-Form Health Survey 
      (SF-36). Human leukocyte antigen (HLA) genotyping was studied to explore whether 
      HLA class I and II allelic distribution differed among MG patients and controls. 
      None of the studied HLA alleles significantly differed between OMG patients and 
      controls. Similarly, none of the alleles with frequencies higher than 15% either 
      in OMG patients or in controls was significantly associated, after Bonferroni 
      correction, with the presence or absence of anti-AChR-Abs in serum.
FAU - Ariatti, Alessandra
AU  - Ariatti A
AD  - Department of Neurosciences, and Department of Onco-Haematology, University 
      Hospitals of Modena & Reggio Emilia , Italy.
FAU - Stefani, Marina
AU  - Stefani M
FAU - Miceli, Pietro
AU  - Miceli P
FAU - Benuzzi, Francesca
AU  - Benuzzi F
FAU - Galassi, Giuliana
AU  - Galassi G
LA  - eng
PT  - Journal Article
DEP - 20131119
PL  - England
TA  - Int J Neurosci
JT  - The International journal of neuroscience
JID - 0270707
RN  - 0 (HLA Antigens)
RN  - 0 (Receptors, Cholinergic)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - HLA Antigens/genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myasthenia Gravis/*diagnosis/genetics/immunology
MH  - *Prognosis
MH  - Quality of Life/*psychology
MH  - Receptors, Cholinergic/immunology
MH  - Severity of Illness Index
EDAT- 2013/11/16 06:00
MHDA- 2015/01/13 06:00
CRDT- 2013/11/16 06:00
PHST- 2013/11/16 06:00 [entrez]
PHST- 2013/11/16 06:00 [pubmed]
PHST- 2015/01/13 06:00 [medline]
AID - 10.3109/00207454.2013.853664 [doi]
PST - ppublish
SO  - Int J Neurosci. 2014 Jun;124(6):427-35. doi: 10.3109/00207454.2013.853664. Epub 
      2013 Nov 19.