PMID- 24229666
OWN - NLM
STAT- MEDLINE
DCOM- 20140514
LR  - 20221207
IS  - 2542-5641 (Electronic)
IS  - 0366-6999 (Linking)
VI  - 126
IP  - 21
DP  - 2013 Nov
TI  - Replication of association study between type 2 diabetes mellitus and IGF2BP2 in 
      Han Chinese population.
PG  - 4013-8
AB  - BACKGROUND: The association between IGF2BP2 and type 2 diabetes mellitus (T2DM) 
      has been repeatedly confirmed among different ethnic populations. However, in 
      several genome-wide association studies (GWAS) from the Chinese Han population, 
      the gene IGF2BP2 has not been replicated. The results of relevant studies for the 
      association between IGF2BP2 and T2DM showed controversy in Chinese Han 
      population. It is necessary to systematically evaluate the contribution of common 
      variants in IGF2BP2 to T2DM in Chinese Han population. METHODS: Two 
      single-nucleotide polymorphisms (SNPs, rs4402960 and rs1470579) in IGF2BP2 were 
      genotyped in Chinese Han population (3807 controls/4531 T2DM cases) by Illumina 
      GoldenGate Indexing assay. The association between SNPs and T2DM was evaluated by 
      multiple Logistic Regression analysis. A meta-analysis was used to estimate the 
      effects of IGF2BP2 in 20854 Chinese Han individuals. RESULTS: rs1470579 and 
      rs4402960 were confirmed to have strong association with T2DM in the Chinese Han 
      population (rs1470579 P = 1.80x10(-7), OR (95% CI) = 1.22 (1.14-1.32), rs4402960 
      P = 7.46x10(-9), OR (95% CI) = 1.26 (1.17-1.37), respectively). Moreover, 11 
      studies for rs4402960 were included in the meta-analysis and 7 studies for 
      rs1470579. The meta-analysis also showed the association between T2DM and IGF2BP2 
      (rs1470579 OR of 1.15 (95% CI = 1.10-1.19), P < 0.0001 under an additive model 
      and rs4402960 OR of 1.14 (95% CI = 1.10-1.18), P < 0.0001 under an additive 
      model). CONCLUSION: IGF2BP2 was strongly associated with the risk of T2DM in 
      Chinese Han population.
FAU - Zhang, Si-Min
AU  - Zhang SM
AD  - Department of Endocrinology and Metabolism, Peking University People's Hospital, 
      Peking University Diabetes Center, Beijing 100044, China.
FAU - Xiao, Jian-Zhong
AU  - Xiao JZ
FAU - Ren, Qian
AU  - Ren Q
FAU - Han, Xue-Yao
AU  - Han XY
FAU - Tang, Yong
AU  - Tang Y
FAU - Yang, Wen-Ying
AU  - Yang WY
FAU - Ji, Li-Nong
AU  - Ji LN
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
RN  - 0 (IGF2BP2 protein, human)
RN  - 0 (RNA-Binding Proteins)
SB  - IM
MH  - Asian People/genetics
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease/genetics
MH  - Genome-Wide Association Study
MH  - Genotype
MH  - Humans
MH  - Linkage Disequilibrium/genetics
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/genetics
MH  - RNA-Binding Proteins/*genetics
EDAT- 2013/11/16 06:00
MHDA- 2014/05/16 06:00
CRDT- 2013/11/16 06:00
PHST- 2013/11/16 06:00 [entrez]
PHST- 2013/11/16 06:00 [pubmed]
PHST- 2014/05/16 06:00 [medline]
PST - ppublish
SO  - Chin Med J (Engl). 2013 Nov;126(21):4013-8.