PMID- 24231094
OWN - NLM
STAT- MEDLINE
DCOM- 20151026
LR  - 20161125
IS  - 0929-6646 (Print)
IS  - 0929-6646 (Linking)
VI  - 113
IP  - 12
DP  - 2014 Dec
TI  - Are statins really wonder drugs?
PG  - 892-8
LID - S0929-6646(13)00331-8 [pii]
LID - 10.1016/j.jfma.2013.05.016 [doi]
AB  - Statins [3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase], are wonder 
      drugs that have reshaped the treatment of hypercholesterolemia and associated 
      cardiovascular diseases. However, evidence from various studies indicates 
      existence of many statin-induced side effects such as myopathies, rhabdomyolysis, 
      hepatotoxicity, peripheral neuropathy, impaired myocardial contractility, 
      diabetes, autoimmune diseases, and erectile dysfunction (ED). Physician awareness 
      of these side effects is reported to be very low even for the adverse effects 
      (AEs) most widely reported by patients. This can lead to incorrect treatment 
      decisions, compromised patient care, and an increase in patient morbidity. 
      Therefore, the aim of this article is to highlight the AEs of statin therapy as 
      well as rational management of these complications to further improve safety of 
      these excellent drugs.
CI  - Copyright (c) 2013. Published by Elsevier B.V.
FAU - Grover, Harpreet Singh
AU  - Grover HS
AD  - Department of Periodontics and Oral Implantology, Sri Gobind Tricentenary Dental 
      College, Hospital and Research Institute, Gurgaon, Haryana, India.
FAU - Luthra, Shailly
AU  - Luthra S
AD  - Department of Periodontics and Oral Implantology, Sri Gobind Tricentenary Dental 
      College, Hospital and Research Institute, Gurgaon, Haryana, India. Electronic 
      address: shaillyluthra@gmail.com.
FAU - Maroo, Shruti
AU  - Maroo S
AD  - Department of Periodontics and Oral Implantology, Sri Gobind Tricentenary Dental 
      College, Hospital and Research Institute, Gurgaon, Haryana, India.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20131111
PL  - Singapore
TA  - J Formos Med Assoc
JT  - Journal of the Formosan Medical Association = Taiwan yi zhi
JID - 9214933
RN  - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
SB  - IM
MH  - Chemical and Drug Induced Liver Injury/etiology
MH  - Diabetes Mellitus/chemically induced
MH  - Humans
MH  - Hydroxymethylglutaryl-CoA Reductase Inhibitors/*adverse effects
MH  - Inflammation/chemically induced
MH  - Kidney Diseases/chemically induced
MH  - Muscular Diseases/*chemically induced
MH  - Nervous System Diseases/chemically induced
OTO - NOTNLM
OT  - adverse effects
OT  - diabetes
OT  - hepatotoxicity
OT  - myopathy
OT  - neuropathy
OT  - statins
EDAT- 2013/11/16 06:00
MHDA- 2015/10/27 06:00
CRDT- 2013/11/16 06:00
PHST- 2013/01/21 00:00 [received]
PHST- 2013/05/04 00:00 [revised]
PHST- 2013/05/11 00:00 [accepted]
PHST- 2013/11/16 06:00 [entrez]
PHST- 2013/11/16 06:00 [pubmed]
PHST- 2015/10/27 06:00 [medline]
AID - S0929-6646(13)00331-8 [pii]
AID - 10.1016/j.jfma.2013.05.016 [doi]
PST - ppublish
SO  - J Formos Med Assoc. 2014 Dec;113(12):892-8. doi: 10.1016/j.jfma.2013.05.016. Epub 
      2013 Nov 11.