PMID- 24231341
OWN - NLM
STAT- MEDLINE
DCOM- 20140902
LR  - 20140113
IS  - 1872-7484 (Electronic)
IS  - 1566-0702 (Linking)
VI  - 180
DP  - 2014 Feb
TI  - Moderate hyperhomocysteinemia provokes dysfunction of cardiovascular autonomic 
      system and liver oxidative stress in rats.
PG  - 43-7
LID - S1566-0702(13)00735-2 [pii]
LID - 10.1016/j.autneu.2013.10.006 [doi]
AB  - Hyperhomocysteinemia (HHcy) is associated with cardiovascular disease, 
      atherosclerosis and reactive oxygen species generation. Thus, our aim was to 
      investigate whether there was an association between HHcy, blood pressure, 
      autonomic control and liver oxidative stress. Male Wistar rats were divided into 
      2 groups and treated for 8weeks: one group (control, CO) received tap water, 
      while the other group (methionine, ME) was given a 100mg/kg of methionine in 
      water by gavage. Two catheters were implanted into the femoral artery and vein to 
      record arterial pressure (AP) and heart rate (HR) and drug administration. 
      Signals were recorded by a data acquisition system. Baroreflex sensitivity was 
      evaluated by HR responses to AP changes induced by vasoactive drugs. HR 
      variability and AP variability were performed by spectral analysis in time and 
      frequency domains to evaluate the contribution of the sympathetic and 
      parasympathetic modulation. Lipid peroxidation and antioxidant enzyme activities 
      were evaluated by measuring superoxide dismutase, catalase and glutathione 
      peroxidase in liver homogenates. The ME group presented a significant increase in 
      systolic arterial pressure (118+/-9 vs 135+/-6mmHg), diastolic arterial pressure 
      (81+/-6 vs. 92+/-4) and mean arterial pressure (95+/-7 vs. 106+/-6). In addition, pulse 
      interval variability presented a significant decrease (41%), while the low 
      frequency component of AP was significantly increased (delta P=6.24mmHg(2)) in 
      the ME group. We also found a positive association between lipid peroxidation and 
      cardiac sympathetic modulation, sympathetic and vagal modulation ratio and 
      systolic pressure variability. Collectively, these findings showed that HHcy 
      induced dysfunction of cardiovascular autonomic system and liver oxidative 
      stress.
CI  - (c) 2013.
FAU - Mendes, R H
AU  - Mendes RH
AD  - Laboratorio de Fisiologia Cardiovascular, Departamento de Fisiologia, Instituto 
      de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Brazil; 
      Instituto de Nutricao Josue de Castro, Universidade Federal do Rio de Janeiro, 
      Brazil.
FAU - Mostarda, C
AU  - Mostarda C
AD  - Hospital Materno Infantil, Universidade Federal do Maranhao, Brazil; Unidade de 
      Hipertensao, Instituto do Coracao, Universidade de Sao Paulo, Brazil.
FAU - Candido, G O
AU  - Candido GO
AD  - Unidade de Hipertensao, Instituto do Coracao, Universidade de Sao Paulo, Brazil.
FAU - Moraes-Silva, I C
AU  - Moraes-Silva IC
AD  - Unidade de Hipertensao, Instituto do Coracao, Universidade de Sao Paulo, Brazil; 
      Programa de Pos-Graduacao em Ciencias da Saude, Universidade Santo Amaro, Brazil.
FAU - D'Almeida, V
AU  - D'Almeida V
AD  - Departamento de Biociencias, UNIFESP, SP, Brazil.
FAU - Bello-Klein, A
AU  - Bello-Klein A
AD  - Laboratorio de Fisiologia Cardiovascular, Departamento de Fisiologia, Instituto 
      de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Brazil.
FAU - Irigoyen, M C
AU  - Irigoyen MC
AD  - Laboratorio de Fisiologia Cardiovascular, Departamento de Fisiologia, Instituto 
      de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Brazil; 
      Unidade de Hipertensao, Instituto do Coracao, Universidade de Sao Paulo, Brazil.
FAU - Rigatto, K
AU  - Rigatto K
AD  - Laboratorio de Fisiologia Cardiovascular, Departamento de Fisiologia, Instituto 
      de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Brazil; 
      Universidade Federal de Ciencias da Saude de Porto Alegre, Brazil. Electronic 
      address: krigatto@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131026
PL  - Netherlands
TA  - Auton Neurosci
JT  - Autonomic neuroscience : basic & clinical
JID - 100909359
RN  - 0 (Reactive Oxygen Species)
RN  - AE28F7PNPL (Methionine)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - Homocysteinemia
SB  - IM
MH  - Animals
MH  - Autonomic Nervous System/drug effects/*physiopathology
MH  - Baroreflex/drug effects/physiology
MH  - Cardiovascular System/drug effects/*physiopathology
MH  - Catalase/analysis
MH  - Glutathione Peroxidase/analysis
MH  - Heart Conduction System/drug effects/physiopathology
MH  - Heart Rate/drug effects/physiology
MH  - Hyperhomocysteinemia/chemically induced/complications/metabolism/*physiopathology
MH  - Hypertension/*etiology/physiopathology
MH  - Lipid Peroxidation/drug effects
MH  - Liver/*metabolism
MH  - Male
MH  - Methionine/toxicity
MH  - *Oxidative Stress
MH  - Rats
MH  - Rats, Wistar
MH  - Reactive Oxygen Species/metabolism
MH  - Superoxide Dismutase/analysis
OTO - NOTNLM
OT  - Autonomic imbalance
OT  - Homocysteine
OT  - Liver oxidative stress
EDAT- 2013/11/16 06:00
MHDA- 2014/09/03 06:00
CRDT- 2013/11/16 06:00
PHST- 2013/06/04 00:00 [received]
PHST- 2013/10/14 00:00 [revised]
PHST- 2013/10/17 00:00 [accepted]
PHST- 2013/11/16 06:00 [entrez]
PHST- 2013/11/16 06:00 [pubmed]
PHST- 2014/09/03 06:00 [medline]
AID - S1566-0702(13)00735-2 [pii]
AID - 10.1016/j.autneu.2013.10.006 [doi]
PST - ppublish
SO  - Auton Neurosci. 2014 Feb;180:43-7. doi: 10.1016/j.autneu.2013.10.006. Epub 2013 
      Oct 26.