PMID- 24231503
OWN - NLM
STAT- MEDLINE
DCOM- 20140116
LR  - 20131115
IS  - 1319-2442 (Print)
IS  - 1319-2442 (Linking)
VI  - 24
IP  - 6
DP  - 2013 Nov
TI  - Immunological aspects of biopsy-proven lupus nephritis in Bahraini patients with 
      systemic lupus erythematosus.
PG  - 1271-9
LID - 10.4103/1319-2442.121286 [doi]
AB  - Lupus nephritis (LN) is a frequent and potentially serious complication of 
      systemic lupus erythematosus (SLE) that may influence morbidity and mortality. 
      Immunological investigations are aiding tools to the kidney biopsy findings in 
      early diagnosis, in addition to monitoring the effect of therapy. The aim of the 
      present study is to highlight the role of these investigations in a group of 
      Bahraini patients and to determine whether there is any positive association 
      between these findings and the outcome of LN. The current study is a 
      retrospective case-control study of randomly selected 88 SLE patients, 44 with 
      biopsy-proven LN and 44 without, acting as controls. All renal biopsies performed 
      during the period from 1996 to 2012 were classified according to the World Health 
      Organization classification. Immunological investigations analyzed are: 
      Antinuclear antibodies (ANA), anti-ds DNA, anti-ENA, anti-cardiolipin antibodies 
      (abs) and complement components C3, C4. Human leukocyte antigen (HLA) typing 
      class II was performed on selected cases. All patients had positive ANA (100%). A 
      significantly high frequency of anti-Smith abs among the non-LN group (43.18%) 
      compared with the LN group (18.18%) was found (P <0.001). On the other hand, the 
      anti-Ro/SSA abs in the non-LN group was also found at a statistically higher 
      frequency (20.45%) compared with that in the LN group (4.54%) (P <0.01). 
      Anti-ds-DNA abs were found to be higher in the LN group (84.09%) compared with 
      the non-LN group (70.45%), but the difference was not statistically significant 
      (P = 0.082). There was a positive association of ANA positivity and low C3 and or 
      C4 in the studied group. In our study, 88.2% of the HLA typed patients had 
      HLADR2, DR3 or both. In conclusion, in our Arabic Bahraini SLE patients, the 
      presence of anti-Smith, anti-Ro/SSA and anti-RNP antibodies and the absence of 
      anti-dsDNA antibodies are independent predictive markers for renal involvement. 
      However, more prospective studies with a larger number of patients are essential 
      to ascertain those findings.
FAU - Farid, Eman M
AU  - Farid EM
AD  - Department of Pathology (Immunology) Salmaniya Medical Complex, Manama, Kingdom 
      of Bahrain.
FAU - Hassan, Adla B
AU  - Hassan AB
FAU - Abalkhail, Ali A
AU  - Abalkhail AA
FAU - El-Agroudy, Amgad E
AU  - El-Agroudy AE
FAU - Arrayed, Sameer Al-M
AU  - Arrayed SA
FAU - Al-Ghareeb, Sumaya M
AU  - Al-Ghareeb SM
LA  - eng
PT  - Journal Article
PL  - Saudi Arabia
TA  - Saudi J Kidney Dis Transpl
JT  - Saudi journal of kidney diseases and transplantation : an official publication of 
      the Saudi Center for Organ Transplantation, Saudi Arabia
JID - 9436968
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (Complement C3)
RN  - 0 (Complement C4)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antibodies, Antinuclear/analysis
MH  - Bahrain
MH  - Case-Control Studies
MH  - Complement C3/analysis
MH  - Complement C4/analysis
MH  - Female
MH  - Humans
MH  - Lupus Erythematosus, Systemic/*complications/immunology
MH  - Lupus Nephritis/*complications/*immunology
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Young Adult
EDAT- 2013/11/16 06:00
MHDA- 2014/01/17 06:00
CRDT- 2013/11/16 06:00
PHST- 2013/11/16 06:00 [entrez]
PHST- 2013/11/16 06:00 [pubmed]
PHST- 2014/01/17 06:00 [medline]
AID - SaudiJKidneyDisTranspl_2013_24_6_1271_121286 [pii]
AID - 10.4103/1319-2442.121286 [doi]
PST - ppublish
SO  - Saudi J Kidney Dis Transpl. 2013 Nov;24(6):1271-9. doi: 10.4103/1319-2442.121286.