PMID- 24233241
OWN - NLM
STAT- MEDLINE
DCOM- 20140227
LR  - 20211203
IS  - 1432-2307 (Electronic)
IS  - 0945-6317 (Linking)
VI  - 464
IP  - 1
DP  - 2014 Jan
TI  - PI3KCA mutation status is of limited prognostic relevance in ER-positive breast 
      cancer patients treated with hormone therapy.
PG  - 85-93
AB  - PI3K/AKT/mTOR pathway alterations are frequent in patients with infiltrating 
      breast cancer (IBC). Their clinical and pathological relevance has been 
      insufficiently documented. We evaluated PI3KCA for mutations and the expression 
      of PTEN, AKT, mTOR and p70S6K by immunohistochemistry in 246 IBC patients treated 
      with hormone therapy (median follow-up, 97 months). A PI3KCA mutation was 
      observed in 50 out of 229 informative cases (21.8 %), PTEN loss in 107 out of 210 
      (51 %), moderate/high level of expression of AKT in 133 out of 188 (71 %), 
      moderate/high level of expression of mTOR in 173 out of 218 (79 %) and 
      moderate/high level of expression of p70S6K in 111 out of 192 cases (58 %). 
      PI3KCA mutation was associated with the absence of Her2/neu 
      amplification/overexpression and a low level of MIB1/Ki-67 labelling. The 
      expression of p70S6K was associated with a high level of mTOR immunoreactivity, 
      and high PTEN expression was associated with high AKT expression level. 
      Univariate analysis showed that PI3KCA mutation status was not associated with 
      clinical outcome in the series as a whole or in the node-negative subgroup. 
      However, in the node-positive subgroup, exon 9 PI3KCA mutation was associated 
      with unfavourable overall survival (OS), although its impact on the final model 
      in multivariate analysis seemed to be limited. Of the other markers, only high 
      p70S6K expression was associated with a significantly prolonged OS. PI3KCA 
      mutation status is of limited prognostic relevance in oestrogen receptor-positive 
      breast cancer patients treated with hormone therapy.
FAU - Cuorvo, Lucia Veronica
AU  - Cuorvo LV
FAU - Verderio, Paolo
AU  - Verderio P
FAU - Ciniselli, Chiara Maura
AU  - Ciniselli CM
FAU - Girlando, Salvatore
AU  - Girlando S
FAU - Decarli, Nicola
AU  - Decarli N
FAU - Leonardi, Elena
AU  - Leonardi E
FAU - Ferro, Antonella
AU  - Ferro A
FAU - Caldara, Alessia
AU  - Caldara A
FAU - Triolo, Renza
AU  - Triolo R
FAU - Eccher, Claudio
AU  - Eccher C
FAU - Cantaloni, Chiara
AU  - Cantaloni C
FAU - Mauri, Francesco
AU  - Mauri F
FAU - Seckl, Michael
AU  - Seckl M
FAU - Volante, Marco
AU  - Volante M
FAU - Buttitta, Fiamma
AU  - Buttitta F
FAU - Marchetti, Antonio
AU  - Marchetti A
FAU - Silvia, Quattrone
AU  - Silvia Q
FAU - Galligioni, Enzo
AU  - Galligioni E
FAU - Palma, Paolo Dalla
AU  - Palma PD
FAU - Barbareschi, Mattia
AU  - Barbareschi M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Virchows Arch
JT  - Virchows Archiv : an international journal of pathology
JID - 9423843
RN  - 0 (Nuclear Proteins)
RN  - 0 (PI3KCA protein, human)
RN  - 0 (Receptors, Estrogen)
RN  - 0 (Receptors, Progesterone)
RN  - 0 (Transcription Factors)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - EC 3.1.3.67 (PTEN Phosphohydrolase)
RN  - EC 3.1.3.67 (PTEN protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Breast Neoplasms/chemistry/drug therapy/*genetics/mortality
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - *Mutation
MH  - Nuclear Proteins/*genetics
MH  - PTEN Phosphohydrolase/analysis
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Receptors, Estrogen/*analysis
MH  - Receptors, Progesterone/analysis
MH  - TOR Serine-Threonine Kinases/analysis
MH  - Transcription Factors/*genetics
EDAT- 2013/11/16 06:00
MHDA- 2014/02/28 06:00
CRDT- 2013/11/16 06:00
PHST- 2013/06/27 00:00 [received]
PHST- 2013/10/21 00:00 [accepted]
PHST- 2013/10/09 00:00 [revised]
PHST- 2013/11/16 06:00 [entrez]
PHST- 2013/11/16 06:00 [pubmed]
PHST- 2014/02/28 06:00 [medline]
AID - 10.1007/s00428-013-1500-7 [doi]
PST - ppublish
SO  - Virchows Arch. 2014 Jan;464(1):85-93. doi: 10.1007/s00428-013-1500-7.