PMID- 24234804
OWN - NLM
STAT- MEDLINE
DCOM- 20140902
LR  - 20211021
IS  - 1573-7373 (Electronic)
IS  - 0167-594X (Print)
IS  - 0167-594X (Linking)
VI  - 116
IP  - 2
DP  - 2014 Jan
TI  - Altered functional connectivity of the default mode network in diffuse gliomas 
      measured with pseudo-resting state fMRI.
PG  - 373-9
AB  - The purpose of the current study was to explore whether brain tumors disrupt the 
      integrity of the default mode network (DMN), a well-characterized resting-state 
      fMRI network. We evaluated whether tumor grade, volume, post-surgical/clinical 
      status, or location decreased the functional connectivity within the DMN in 
      patients with gliomas. Task-based fMRI data was obtained from 68 diffuse glioma 
      patients and 12 healthy volunteers. Pseudo-resting state fMRI data was calculated 
      from task-based fMRI data using standard techniques. Data was preprocessed and 
      DMN integrity was compared across WHO grade, tumor volume surgical status (new 
      vs. recurrent tumors), age, and KPS using univariate and multivariate linear 
      models. WHO grade was the most significant predictor of DMN integrity (P = 
      0.004), whereas T2 hyperintense lesion volume was not a predictor (P = 0.154). 
      DMN integrity was lower in high-grade (WHO III-IV) compared with low-grade (WHO 
      II) patients (P = 0.020). Tumors in the left parietal lobe showed a more impaired 
      DMN compared with tumors in the frontal lobe, while tumors within and outside the 
      network nodes did not differ significantly. Results suggest higher tumor grade 
      along with prior surgery and/or treatment cause the largest reduction in DMN 
      functional connectivity in patients with primary gliomas, and that tumor location 
      has an impact on connectivity.
FAU - Harris, Robert J
AU  - Harris RJ
FAU - Bookheimer, Susan Y
AU  - Bookheimer SY
FAU - Cloughesy, Timothy F
AU  - Cloughesy TF
FAU - Kim, Hyun J
AU  - Kim HJ
FAU - Pope, Whitney B
AU  - Pope WB
FAU - Lai, Albert
AU  - Lai A
FAU - Nghiemphu, Phioanh L
AU  - Nghiemphu PL
FAU - Liau, Linda M
AU  - Liau LM
FAU - Ellingson, Benjamin M
AU  - Ellingson BM
LA  - eng
GR  - R21 CA167354/CA/NCI NIH HHS/United States
GR  - R21CA167354/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurooncol
JT  - Journal of neuro-oncology
JID - 8309335
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Analysis of Variance
MH  - Brain/blood supply/*physiopathology
MH  - Brain Neoplasms/*pathology
MH  - Female
MH  - Glioma/*pathology
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Nerve Net/blood supply/*physiopathology
MH  - Neural Pathways/blood supply/*physiopathology
MH  - Oxygen/blood
MH  - *Rest
MH  - Survival Analysis
PMC - PMC6763342
MID - NIHMS1049003
EDAT- 2013/11/16 06:00
MHDA- 2014/09/03 06:00
PMCR- 2019/09/26
CRDT- 2013/11/16 06:00
PHST- 2013/08/06 00:00 [received]
PHST- 2013/11/01 00:00 [accepted]
PHST- 2013/11/16 06:00 [entrez]
PHST- 2013/11/16 06:00 [pubmed]
PHST- 2014/09/03 06:00 [medline]
PHST- 2019/09/26 00:00 [pmc-release]
AID - 10.1007/s11060-013-1304-2 [doi]
PST - ppublish
SO  - J Neurooncol. 2014 Jan;116(2):373-9. doi: 10.1007/s11060-013-1304-2.