PMID- 24234836
OWN - NLM
STAT- MEDLINE
DCOM- 20141201
LR  - 20140128
IS  - 1440-1614 (Electronic)
IS  - 0004-8674 (Linking)
VI  - 48
IP  - 2
DP  - 2014 Feb
TI  - Lower anterior cingulate volume in seriously violent men with antisocial 
      personality disorder or schizophrenia and a history of childhood abuse.
PG  - 153-61
LID - 10.1177/0004867413512690 [doi]
AB  - OBJECTIVE: Antisocial personality disorder (ASPD) and schizophrenia, as well as 
      childhood abuse, are associated with violent behaviour and show marked volumetric 
      reduction in the anterior cingulate (AC), a brain region implicated in regulation 
      of violence through its involvement in decision making, empathy, impulse control, 
      and emotion regulation. The present study examined, for the first time to the 
      authors' knowledge, the grey matter volume of the AC in relation to seriously 
      violent behaviour and childhood psychosocial deprivation (including physical and 
      sexual abuse) in the context of a mental disorder (schizophrenia or ASPD). 
      METHODS: Fifty-seven men [14 with ASPD and a history of serious violence; 13 with 
      schizophrenia and a history of serious violence (VSZ); 15 with schizophrenia 
      without a violence history (SZ); 15 nonviolent healthy participants] underwent 
      whole-brain magnetic resonance imaging and were rated on the presence of physical 
      abuse, sexual abuse, neglect, extreme poverty, foster home placement, criminal 
      parent, severe family conflict, and broken home (collectively 'psychosocial 
      deprivation'). Stereological volumetric ratings of the AC were examined for group 
      differences and their association with childhood psychosocial deprivation. 
      RESULTS: A higher proportion of ASPD and VSZ patients had suffered psychosocial 
      deprivation as children, in particular severe physical abuse, relative to SZ 
      patients and healthy participants. ASPD and VSZ, but not SZ, patients had 
      significantly lower AC volume relative to healthy participants. AC volumes 
      correlated negatively with (total) psychosocial deprivation as well as physical 
      and sexual abuse ratings. Group differences in AC volume became nonsignificant 
      when psychosocial deprivation ratings were covaried for. CONCLUSIONS: Violent 
      mentally disordered individuals with ASPD or schizophrenia suffer from a 
      significant AC volume loss and this deficit, at least in part, is explained by 
      their histories of stressful childhood experiences. Current and future therapies 
      aiming to reduce violence in such populations would benefit by attending to 
      biological (and other) correlates of childhood abuse.
FAU - Kumari, Veena
AU  - Kumari V
AD  - 1Department of Psychology, Institute of Psychiatry, King's College London, 
      London, UK.
FAU - Uddin, Shahir
AU  - Uddin S
FAU - Premkumar, Preethi
AU  - Premkumar P
FAU - Young, Susan
AU  - Young S
FAU - Gudjonsson, Gisli H
AU  - Gudjonsson GH
FAU - Raghuvanshi, Satya
AU  - Raghuvanshi S
FAU - Barkataki, Ian
AU  - Barkataki I
FAU - Sumich, Alexander
AU  - Sumich A
FAU - Taylor, Pamela
AU  - Taylor P
FAU - Das, Mrigendra
AU  - Das M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131114
PL  - England
TA  - Aust N Z J Psychiatry
JT  - The Australian and New Zealand journal of psychiatry
JID - 0111052
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Adult Survivors of Child Abuse/*psychology
MH  - Antisocial Personality Disorder/*pathology/psychology
MH  - Atrophy/pathology
MH  - Case-Control Studies
MH  - Gyrus Cinguli/*pathology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers, Unmyelinated/pathology
MH  - Neuroimaging
MH  - Psychosocial Deprivation
MH  - Schizophrenia/*pathology
MH  - Violence/*psychology
OTO - NOTNLM
OT  - Anterior cingulate
OT  - MRI
OT  - physical abuse
OT  - psychosocial deprivation
OT  - sexual abuse
OT  - violence
EDAT- 2013/11/16 06:00
MHDA- 2014/12/15 06:00
CRDT- 2013/11/16 06:00
PHST- 2013/11/16 06:00 [entrez]
PHST- 2013/11/16 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - 0004867413512690 [pii]
AID - 10.1177/0004867413512690 [doi]
PST - ppublish
SO  - Aust N Z J Psychiatry. 2014 Feb;48(2):153-61. doi: 10.1177/0004867413512690. Epub 
      2013 Nov 14.