PMID- 2423685
OWN - NLM
STAT- MEDLINE
DCOM- 19860716
LR  - 20181130
IS  - 0022-3565 (Print)
IS  - 0022-3565 (Linking)
VI  - 237
IP  - 3
DP  - 1986 Jun
TI  - Modification of serotonergic and noradrenergic neurotransmissions by repeated 
      administration of monoamine oxidase inhibitors: electrophysiological studies in 
      the rat central nervous system.
PG  - 987-94
AB  - The net effect of repeated administration of monoamine oxidase inhibitors (MAOI) 
      on central serotonergic (5-HT) and noradrenergic (NE) neurotransmissions was 
      studied by assessing the responsiveness of hippocampal pyramidal neurons to 
      microiontophoretically applied 5-HT and NE and the response of these neurons to 
      the electrical activation of the 5-HT and NE ascending pathways. Brain monoamine 
      oxidase (MAO) activity as well as the levels of 5-HT, NE and their metabolites 
      were determined in order to verify the biochemical effects of the drugs 
      administered. Twenty-one-day treatments with clorgyline and deprenyl inhibited 
      very selectively MAO-A and MAO-B, respectively, whereas a treatment with 
      phenelzine inhibited both forms of the enzyme. Whole brain concentrations of 5-HT 
      and NE were increased by the antidepressant drugs clorgyline and phenelzine 
      whereas deprenyl, an MAOI type B ineffective in endogenous depression, increased 
      only NE levels after a 21-day treatment. The responsiveness of hippocampal 
      pyramidal neurons to 5-HT was decreased by the long-term clorgyline treatment, 
      but not by deprenyl and phenelzine, whereas that to NE was not altered by any of 
      the treatments. The suppression of firing of these same neurons induced by the 
      stimulation of the 5-HT pathway was increased by clorgyline and phenelzine, but 
      not by deprenyl. The effect of the stimulation of the dorsal NE bundle was not 
      modified by any of the treatments. These data show that prolonged inhibition of 
      MAO-A, but not that of MAO-B, results in an enhanced 5-HT 
      neurotransmission.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Blier, P
AU  - Blier P
FAU - De Montigny, C
AU  - De Montigny C
FAU - Azzaro, A J
AU  - Azzaro AJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Pharmacol Exp Ther
JT  - The Journal of pharmacology and experimental therapeutics
JID - 0376362
RN  - 0 (Monoamine Oxidase Inhibitors)
RN  - 333DO1RDJY (Serotonin)
RN  - 534-82-7 (Methoxyhydroxyphenylglycol)
RN  - 54-16-0 (Hydroxyindoleacetic Acid)
RN  - EC 1.4.3.4 (Monoamine Oxidase)
RN  - N9YNS0M02X (Acetylcholine)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Acetylcholine/pharmacology
MH  - Animals
MH  - Brain/*drug effects
MH  - Brain Chemistry
MH  - Hippocampus/drug effects/physiology
MH  - Hydroxyindoleacetic Acid/analysis
MH  - Male
MH  - Methoxyhydroxyphenylglycol/analysis
MH  - Monoamine Oxidase/analysis
MH  - Monoamine Oxidase Inhibitors/*pharmacology
MH  - Norepinephrine/analysis/*metabolism/pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Serotonin/analysis/*metabolism/pharmacology
MH  - Synaptic Transmission/*drug effects
EDAT- 1986/06/01 00:00
MHDA- 1986/06/01 00:01
CRDT- 1986/06/01 00:00
PHST- 1986/06/01 00:00 [pubmed]
PHST- 1986/06/01 00:01 [medline]
PHST- 1986/06/01 00:00 [entrez]
PST - ppublish
SO  - J Pharmacol Exp Ther. 1986 Jun;237(3):987-94.