PMID- 24237303
OWN - NLM
STAT- MEDLINE
DCOM- 20141016
LR  - 20181202
IS  - 1557-8577 (Electronic)
IS  - 1549-1684 (Linking)
VI  - 17
IP  - 1
DP  - 2014 Feb
TI  - Towards reaching the target: clinical application of mesenchymal stem cells for 
      diabetic foot ulcers.
PG  - 40-53
LID - 10.1089/rej.2013.1467 [doi]
AB  - Mesenchymal stem cells (MSCs) hold great promise for therapeutic application in 
      non-healing ulcers and tissue regeneration because of their multi-lineage 
      differentiation potential. MSCs delivered may migrate to the sites of injury and 
      improve wound healing by stimulating angiogenesis and promoting 
      revascularization. The incidence of type 2 diabetes mellitus (T2DM) is increasing 
      worldwide. It is associated with peripheral neuropathy and peripheral arterial 
      occlusive disease (PAOD), which predispose patients to develop non-healing foot 
      ulcers following minor trauma. A high rate of amputation exists among diabetic 
      patients due to non-healing foot ulcers, which are a significant burden for the 
      society despite new therapeutic protocols developed. In recent years, stem cell 
      transplantation has been considered as a new therapeutic option for diabetic foot 
      ulcers (DFUs). The regeneration potential of MSCs has been demonstrated in the 
      experimental and clinical trials. Here we review the potential efficacy and 
      systematic use of MSCs for the treatment of non-healing DFUs, current advances, 
      MSC delivery systems, and possible options to enhance the therapeutic potential 
      of stem cell for wound healing.
FAU - Dash, Surjya Narayan
AU  - Dash SN
AD  - 1 Department of Zoology, Utkal University , Bhubaneswar, Odisha, India .
FAU - Dash, Nihar Ranjan
AU  - Dash NR
FAU - Guru, Bhikaricharan
AU  - Guru B
FAU - Mohapatra, Prakash Chandra
AU  - Mohapatra PC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Rejuvenation Res
JT  - Rejuvenation research
JID - 101213381
SB  - IM
MH  - Diabetic Foot/*complications/pathology/*therapy
MH  - Foot Ulcer/*complications/pathology/*therapy
MH  - Humans
MH  - *Mesenchymal Stem Cell Transplantation
MH  - Mesenchymal Stem Cells/*cytology
MH  - Wound Healing
EDAT- 2013/11/19 06:00
MHDA- 2014/10/17 06:00
CRDT- 2013/11/19 06:00
PHST- 2013/11/19 06:00 [entrez]
PHST- 2013/11/19 06:00 [pubmed]
PHST- 2014/10/17 06:00 [medline]
AID - 10.1089/rej.2013.1467 [doi]
PST - ppublish
SO  - Rejuvenation Res. 2014 Feb;17(1):40-53. doi: 10.1089/rej.2013.1467.