PMID- 24237698
OWN - NLM
STAT- MEDLINE
DCOM- 20140707
LR  - 20211021
IS  - 1934-6069 (Electronic)
IS  - 1931-3128 (Print)
IS  - 1931-3128 (Linking)
VI  - 14
IP  - 5
DP  - 2013 Nov 13
TI  - The intracellular cargo receptor ERGIC-53 is required for the production of 
      infectious arenavirus, coronavirus, and filovirus particles.
PG  - 522-34
LID - S1931-3128(13)00372-7 [pii]
LID - 10.1016/j.chom.2013.10.010 [doi]
AB  - Arenaviruses and hantaviruses cause severe human disease. Little is known 
      regarding host proteins required for their propagation. We identified human 
      proteins that interact with the glycoproteins (GPs) of a prototypic arenavirus 
      and hantavirus and show that the lectin endoplasmic reticulum (ER)-Golgi 
      intermediate compartment 53 kDa protein (ERGIC-53), a cargo receptor required for 
      glycoprotein trafficking within the early exocytic pathway, associates with 
      arenavirus, hantavirus, coronavirus, orthomyxovirus, and filovirus GPs. ERGIC-53 
      binds to arenavirus GPs through a lectin-independent mechanism, traffics to 
      arenavirus budding sites, and is incorporated into virions. ERGIC-53 is required 
      for arenavirus, coronavirus, and filovirus propagation; in its absence, 
      GP-containing virus particles form but are noninfectious, due in part to their 
      inability to attach to host cells. Thus, we have identified a class of 
      pathogen-derived ERGIC-53 ligands, a lectin-independent basis for their 
      association with ERGIC-53, and a role for ERGIC-53 in the propagation of several 
      highly pathogenic RNA virus families.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Klaus, Joseph P
AU  - Klaus JP
AD  - Department of Medicine, Division of Immunobiology, University of Vermont, 
      Burlington, VT 05405, USA; Cellular, Molecular and Biomedical Sciences Graduate 
      Program, University of Vermont, Burlington, VT 05405, USA.
FAU - Eisenhauer, Philip
AU  - Eisenhauer P
FAU - Russo, Joanne
AU  - Russo J
FAU - Mason, Anne B
AU  - Mason AB
FAU - Do, Danh
AU  - Do D
FAU - King, Benjamin
AU  - King B
FAU - Taatjes, Douglas
AU  - Taatjes D
FAU - Cornillez-Ty, Cromwell
AU  - Cornillez-Ty C
FAU - Boyson, Jonathan E
AU  - Boyson JE
FAU - Thali, Markus
AU  - Thali M
FAU - Zheng, Chunlei
AU  - Zheng C
FAU - Liao, Lujian
AU  - Liao L
FAU - Yates, John R 3rd
AU  - Yates JR 3rd
FAU - Zhang, Bin
AU  - Zhang B
FAU - Ballif, Bryan A
AU  - Ballif BA
FAU - Botten, Jason W
AU  - Botten JW
LA  - eng
GR  - P20 GM103449/GM/NIGMS NIH HHS/United States
GR  - R01 HL094505/HL/NHLBI NIH HHS/United States
GR  - R01 AI080302/AI/NIAID NIH HHS/United States
GR  - R21 AI088059/AI/NIAID NIH HHS/United States
GR  - S10 RR019246/RR/NCRR NIH HHS/United States
GR  - T32 AI055402/AI/NIAID NIH HHS/United States
GR  - U54 AI065359/AI/NIAID NIH HHS/United States
GR  - 8P20GM103449/GM/NIGMS NIH HHS/United States
GR  - P20 GM103496/GM/NIGMS NIH HHS/United States
GR  - P20 RR021905/RR/NCRR NIH HHS/United States
GR  - P41 GM103533/GM/NIGMS NIH HHS/United States
GR  - P20RR021905/RR/NCRR NIH HHS/United States
GR  - 1S10RR019246/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Cell Host Microbe
JT  - Cell host & microbe
JID - 101302316
RN  - 0 (Glycoproteins)
RN  - 0 (LMAN1 protein, human)
RN  - 0 (Mannose-Binding Lectins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Viral Proteins)
SB  - IM
CIN - Cell Host Microbe. 2013 Nov 13;14(5):485-7. PMID: 24237693
MH  - Arenavirus/*physiology
MH  - Cell Line
MH  - Coronavirus/*physiology
MH  - Filoviridae/*physiology
MH  - Glycoproteins/metabolism
MH  - Humans
MH  - Mannose-Binding Lectins/*metabolism
MH  - Membrane Proteins/*metabolism
MH  - Protein Transport
MH  - Viral Proteins/metabolism
MH  - *Virus Assembly
PMC - PMC3999090
MID - NIHMS537878
EDAT- 2013/11/19 06:00
MHDA- 2014/07/08 06:00
PMCR- 2013/11/13
CRDT- 2013/11/19 06:00
PHST- 2013/03/07 00:00 [received]
PHST- 2013/08/02 00:00 [revised]
PHST- 2013/09/18 00:00 [accepted]
PHST- 2013/11/19 06:00 [entrez]
PHST- 2013/11/19 06:00 [pubmed]
PHST- 2014/07/08 06:00 [medline]
PHST- 2013/11/13 00:00 [pmc-release]
AID - S1931-3128(13)00372-7 [pii]
AID - 10.1016/j.chom.2013.10.010 [doi]
PST - ppublish
SO  - Cell Host Microbe. 2013 Nov 13;14(5):522-34. doi: 10.1016/j.chom.2013.10.010.