PMID- 24237962
OWN - NLM
STAT- MEDLINE
DCOM- 20140409
LR  - 20220331
IS  - 1742-4658 (Electronic)
IS  - 1742-464X (Linking)
VI  - 281
IP  - 3
DP  - 2014 Feb
TI  - The effects of acute and chronic exercise on PGC-1alpha, irisin and browning of 
      subcutaneous adipose tissue in humans.
PG  - 739-49
LID - 10.1111/febs.12619 [doi]
AB  - Irisin was first identified as a peroxisome proliferator-activated receptor gamma 
      co-activator-1alpha (PGC-1alpha) dependent myokine with the potential to induce murine 
      brown-fat-like development of white adipose tissue. In humans, the regulatory 
      effect of training on muscle FNDC5 mRNA expression and subsequently irisin levels 
      in plasma is more controversial. We recruited 26 inactive men (13 normoglycaemic 
      and normal weight, controls; and 13 slightly hyperglycaemic and overweight, 
      pre-diabetes group) aged 40-65 years for a 12-week intervention of combined 
      endurance and strength training with four sessions of training per week. Before 
      and after the 12-week intervention period, participants were exposed to an acute 
      endurance workload of 45 min at 70% of VO(2max), and muscle biopsies were taken 
      prior to and after exercise. Skeletal muscle mRNA for PGC1A and FNDC5 correlated 
      and both PGC1A and FNDC5 mRNA levels increased after 12 weeks of training in both 
      control and pre-diabetes subjects. Circulating irisin was reduced in response to 
      12 weeks of training, and was increased acutely (~1.2-fold) just after acute 
      exercise. Plasma concentration of irisin was higher in pre-diabetes subjects 
      compared with controls. There was little effect of 12 weeks of training on 
      selected browning genes in subcutaneous adipose tissue. UCP1 mRNA did not 
      correlate with FNDC5 expression in subcutaneous adipose tissue or skeletal muscle 
      or with irisin levels in plasma. We observed no enhancing effect of long-term 
      training on circulating irisin levels, and little or no effect of training on 
      browning of subcutaneous white adipose tissue in humans.
CI  - (c) 2013 FEBS.
FAU - Norheim, Frode
AU  - Norheim F
AD  - Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, 
      Norway.
FAU - Langleite, Torgrim Mikal
AU  - Langleite TM
FAU - Hjorth, Marit
AU  - Hjorth M
FAU - Holen, Torgeir
AU  - Holen T
FAU - Kielland, Anders
AU  - Kielland A
FAU - Stadheim, Hans Kristian
AU  - Stadheim HK
FAU - Gulseth, Hanne Lovdal
AU  - Gulseth HL
FAU - Birkeland, Kare Inge
AU  - Birkeland KI
FAU - Jensen, Jorgen
AU  - Jensen J
FAU - Drevon, Christian A
AU  - Drevon CA
LA  - eng
PT  - Comparative Study
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131210
PL  - England
TA  - FEBS J
JT  - The FEBS journal
JID - 101229646
RN  - 0 (FNDC5 protein, human)
RN  - 0 (Fibronectins)
RN  - 0 (Ion Channels)
RN  - 0 (Mitochondrial Proteins)
RN  - 0 (PPARGC1A protein, human)
RN  - 0 (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha)
RN  - 0 (Pigments, Biological)
RN  - 0 (RNA, Messenger)
RN  - 0 (Transcription Factors)
RN  - 0 (UCP1 protein, human)
RN  - 0 (Uncoupling Protein 1)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Body Mass Index
MH  - *Exercise
MH  - Fibronectins/blood/genetics/*metabolism
MH  - Humans
MH  - Ion Channels/genetics/metabolism
MH  - Male
MH  - Middle Aged
MH  - Mitochondrial Proteins/genetics/metabolism
MH  - Motor Activity
MH  - Muscle, Skeletal/*metabolism
MH  - Overweight/complications
MH  - Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
MH  - Physical Endurance
MH  - Pigments, Biological/genetics/*metabolism
MH  - Prediabetic State/blood/complications/metabolism/*therapy
MH  - RNA, Messenger/metabolism
MH  - Resistance Training
MH  - Subcutaneous Fat, Abdominal/chemistry/*drug effects/metabolism
MH  - Transcription Factors/biosynthesis/genetics/*metabolism
MH  - Transcription, Genetic
MH  - Uncoupling Protein 1
OTO - NOTNLM
OT  - FNDC5
OT  - PGC-1alpha
OT  - UCP1
OT  - exercise
OT  - irisin
EDAT- 2013/11/19 06:00
MHDA- 2014/04/10 06:00
CRDT- 2013/11/19 06:00
PHST- 2013/08/16 00:00 [received]
PHST- 2013/11/07 00:00 [revised]
PHST- 2013/11/12 00:00 [accepted]
PHST- 2013/11/19 06:00 [entrez]
PHST- 2013/11/19 06:00 [pubmed]
PHST- 2014/04/10 06:00 [medline]
AID - 10.1111/febs.12619 [doi]
PST - ppublish
SO  - FEBS J. 2014 Feb;281(3):739-49. doi: 10.1111/febs.12619. Epub 2013 Dec 10.