PMID- 24238107
OWN - NLM
STAT- MEDLINE
DCOM- 20141222
LR  - 20181202
IS  - 1600-0897 (Electronic)
IS  - 1046-7408 (Linking)
VI  - 70
IP  - 6
DP  - 2013 Dec
TI  - Intravenous immunoglobulin treatment for repeated IVF/ICSI failure and 
      unexplained infertility: a systematic review and a meta-analysis.
PG  - 434-47
LID - 10.1111/aji.12170 [doi]
AB  - Intravenous immunoglobulin (IVIG) has been introduced empirically into IVF/ICSI 
      programs with the hopes of improving in vitro fertilization (IVF) success. 
      However, the effects of IVIG have been inconsistent. We investigated the effects 
      of IVIG on hard outcomes, including implantation rate, clinical pregnancy rate, 
      live birth rate, miscarriage rate, and live birth rate per embryo transferred. 
      The PubMed, EMBASE, and CNKI databases were searched up to June of 2013 and 10 
      studies were included. Case-controlled studies comparing IVIG with placebo in 
      IVF/ICSI women and/or unexplained infertility were included. Using fixed and 
      random effects models, the pooled risk ratios (RR) with 95% confidence intervals 
      (CIs) were calculated. The use of IVIG was significantly associated with a higher 
      implantation rate and RR was 2.708 (95%CI: 1.302-5.629) compared with the 
      placebo. The clinical pregnancy rate and the live birth rate were significantly 
      increased in patients randomized to IVIG; RR was 1.475 (95%CI: 1.191-1.825) for 
      the clinical pregnancy rate and RR was 1.616 (95%CI: 1.243-2.101) for the live 
      birth rate. Moreover, the miscarriage rate was significantly less in patients 
      randomized to IVIG (0.352, 95%CI: 0.168-0.738), but the live birthrate per embryo 
      transferred was not (2.893; 95%CI: 0.810-10.331) less. Our results strongly 
      support that IVIG is a useful treatment option for women undergoing repeated IVF 
      failure.
CI  - (c) 2013 John Wiley & Sons Ltd.
FAU - Li, Jie
AU  - Li J
AD  - Guangxi Reproductive Medical Research Center, First Affiliated Hospital of 
      Guangxi Medical University, Nanning, China.
FAU - Chen, Yang
AU  - Chen Y
FAU - Liu, Chengjun
AU  - Liu C
FAU - Hu, Yanling
AU  - Hu Y
FAU - Li, Liuming
AU  - Li L
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
PL  - Denmark
TA  - Am J Reprod Immunol
JT  - American journal of reproductive immunology (New York, N.Y. : 1989)
JID - 8912860
RN  - 0 (Immunoglobulins, Intravenous)
SB  - IM
MH  - Embryo Implantation/drug effects/immunology
MH  - Female
MH  - Fertilization in Vitro/*methods
MH  - Humans
MH  - Immunoglobulins, Intravenous/administration & dosage/*immunology/*therapeutic use
MH  - Infertility/drug therapy/*immunology
OTO - NOTNLM
OT  - ICSI
OT  - immunoglobulin
OT  - in vitro fertilization
OT  - infertility
OT  - intravenous immunoglobulin
OT  - meta-analysis
EDAT- 2013/11/19 06:00
MHDA- 2014/12/23 06:00
CRDT- 2013/11/19 06:00
PHST- 2013/08/21 00:00 [received]
PHST- 2013/10/03 00:00 [accepted]
PHST- 2013/11/19 06:00 [entrez]
PHST- 2013/11/19 06:00 [pubmed]
PHST- 2014/12/23 06:00 [medline]
AID - 10.1111/aji.12170 [doi]
PST - ppublish
SO  - Am J Reprod Immunol. 2013 Dec;70(6):434-47. doi: 10.1111/aji.12170.