PMID- 24238213
OWN - NLM
STAT- MEDLINE
DCOM- 20141218
LR  - 20151119
IS  - 1742-7843 (Electronic)
IS  - 1742-7835 (Linking)
VI  - 114
IP  - 5
DP  - 2014 May
TI  - Late adverse events after enhanced and unenhanced MRI and CT: a prospective 
      study.
PG  - 427-35
LID - 10.1111/bcpt.12175 [doi]
AB  - Prospective evaluation of frequency of late and very late adverse events in 
      patients undergoing enhanced or unenhanced magnetic resonance imaging (MRI) or 
      computed tomography (CT). The imaging procedure was performed according to the 
      protocols of the department. All patients were contacted 3 days after their 
      imaging procedure for the occurrence of late adverse events (LAEs) and a month 
      later for the occurrence of very late adverse events (VLAEs) using a structured 
      questionnaire. A total of 1042 (71%) among 1473 patients completed both the 3-day 
      and 1-month questionnaire. The incidence of LAEs was significantly higher in the 
      enhanced MRI (38%) and CT (27%) groups than unenhanced MRI (20%) and CT (16%) 
      groups. The frequency of nausea, dizziness, abdominal pain and diarrhoea was 
      significantly higher in the enhanced MRI group than in the MRI control group, 
      while taste sensation was reported more frequent in the enhanced CT group than in 
      the CT control group. The incidence of VLAEs was significantly higher in the 
      enhanced CT (21%) than unenhanced CT group (13%). The same LAEs and VLAEs were 
      reported in all four groups. LAEs and VLAEs were reported more often in patients 
      with allergy in both the enhanced and unenhanced groups. The incidence of LAEs 
      and VLAEs was higher in the enhanced groups than in the unenhanced groups. The 
      most reported adverse events in the enhanced groups were also reported in the 
      unenhanced groups. Patients with allergy reported LAE and VLAE more often. This 
      suggests that adverse events may not always be caused by the contrast media.
CI  - (c) 2013 Nordic Association for the Publication of BCPT (former Nordic 
      Pharmacological Society).
FAU - Azzouz, Manal
AU  - Azzouz M
AD  - Department of Diagnostic Radiology, Copenhagen University Hospital Herlev, 
      Herlev, Denmark.
FAU - Romsing, Janne
AU  - Romsing J
FAU - Thomsen, Henrik S
AU  - Thomsen HS
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131216
PL  - England
TA  - Basic Clin Pharmacol Toxicol
JT  - Basic & clinical pharmacology & toxicology
JID - 101208422
RN  - 0 (Contrast Media)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Contrast Media/*administration & dosage/adverse effects
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Incidence
MH  - Magnetic Resonance Imaging/*adverse effects/methods
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Surveys and Questionnaires
MH  - Time Factors
MH  - Tomography, X-Ray Computed/*adverse effects/methods
MH  - Young Adult
EDAT- 2013/11/19 06:00
MHDA- 2014/12/19 06:00
CRDT- 2013/11/19 06:00
PHST- 2013/08/23 00:00 [received]
PHST- 2013/11/04 00:00 [accepted]
PHST- 2013/11/19 06:00 [entrez]
PHST- 2013/11/19 06:00 [pubmed]
PHST- 2014/12/19 06:00 [medline]
AID - 10.1111/bcpt.12175 [doi]
PST - ppublish
SO  - Basic Clin Pharmacol Toxicol. 2014 May;114(5):427-35. doi: 10.1111/bcpt.12175. 
      Epub 2013 Dec 16.