PMID- 24238729
OWN - NLM
STAT- MEDLINE
DCOM- 20150528
LR  - 20221207
IS  - 1878-7533 (Electronic)
IS  - 1550-7289 (Linking)
VI  - 10
IP  - 4
DP  - 2014 Jul-Aug
TI  - Duodenal-jejunal bypass for the treatment of type 2 diabetes in Chinese patients 
      with an average body mass index<24 kg/m2.
PG  - 641-6
LID - S1550-7289(13)00294-3 [pii]
LID - 10.1016/j.soard.2013.09.001 [doi]
AB  - BACKGROUND: It is frequently reported that bariatric surgery often leads to 
      resolution of type 2 diabetes mellitus (T2 DM). Limited experience with 
      duodenal-jejunal bypass (DJB) for the treatment of T2 DM has shown controversial 
      results. We present the first study of DJB for T2 DM patients in China. The 
      objective of this study was to evaluate the effects of DJB in nonobese Chinese 
      patients with T2 DM. METHODS: From March 2009 to March 2011, a total of 10 T2 DM 
      patients with an average body mass index (BMI) of 23.8 +/- 1.2 kg/m(2) were 
      enrolled in the study. DJB was performed in all patients. BMI and glycometabolic 
      parameters were collected at baseline and 1, 3, 6, 12, and 24 months 
      postoperatively. Remission of T2 DM was defined as a glycosylated hemoglobin 
      (HbA1c) level of<7% without diabetic medication. RESULTS: Remission of T2 DM was 
      observed in 1 (10%) of 10 T2 DM patients at 6 months. Without increasing 
      antihyperglycemic agents, fasting plasma glucose (FPG), 2-hour postprandial 
      plasma glucose, and HbA1c decreased significantly at each postoperative time 
      point, compared with the preoperative baseline. BMI statistically decreased at 1 
      and 3 months, but did not reach statistical significance at 6, 12, and 24 months. 
      CONCLUSIONS: DJB can improve glycemic control in nonobese T2 DM patients without 
      significant weight loss but may not be effective enough to induce remission of T2 
      DM in nonobese Chinese patients. A larger sample size and more constrictive 
      inclusion criteria may be required for better evaluation.
CI  - (c) 2013 American Society for Bariatric Surgery Published by American Society for 
      Metabolic and Bariatric Surgery All rights reserved.
FAU - Jiang, Feizhao
AU  - Jiang F
AD  - Metabolic & Bariatric Surgery, First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, People's Republic of China.
FAU - Zhu, Hengliang
AU  - Zhu H
AD  - Metabolic & Bariatric Surgery, First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, People's Republic of China. Electronic address: 
      dr.brownhenry@yahoo.com.
FAU - Zheng, Xiaofeng
AU  - Zheng X
AD  - Metabolic & Bariatric Surgery, First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, People's Republic of China.
FAU - Tu, Jinfu
AU  - Tu J
AD  - Metabolic & Bariatric Surgery, First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, People's Republic of China.
FAU - Zhang, Weijian
AU  - Zhang W
AD  - Metabolic & Bariatric Surgery, First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, People's Republic of China.
FAU - Xie, Xuemeng
AU  - Xie X
AD  - Metabolic & Bariatric Surgery, First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, People's Republic of China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130913
PL  - United States
TA  - Surg Obes Relat Dis
JT  - Surgery for obesity and related diseases : official journal of the American 
      Society for Bariatric Surgery
JID - 101233161
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Hypoglycemic Agents)
SB  - IM
MH  - Adult
MH  - *Anastomosis, Surgical
MH  - *Asian People
MH  - *Bariatric Surgery
MH  - Blood Glucose/metabolism
MH  - Body Mass Index
MH  - China
MH  - Diabetes Mellitus, Type 2/drug therapy/ethnology/*surgery
MH  - Duodenum/*surgery
MH  - Female
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Hypoglycemic Agents/therapeutic use
MH  - Jejunum/*surgery
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Treatment Outcome
MH  - Weight Loss
OTO - NOTNLM
OT  - Bariatric surgery
OT  - DJB
OT  - Duodenal-jejunal bypass
OT  - Type 2 diabetes mellitus
EDAT- 2013/11/19 06:00
MHDA- 2015/05/29 06:00
CRDT- 2013/11/19 06:00
PHST- 2013/05/15 00:00 [received]
PHST- 2013/09/02 00:00 [revised]
PHST- 2013/09/05 00:00 [accepted]
PHST- 2013/11/19 06:00 [entrez]
PHST- 2013/11/19 06:00 [pubmed]
PHST- 2015/05/29 06:00 [medline]
AID - S1550-7289(13)00294-3 [pii]
AID - 10.1016/j.soard.2013.09.001 [doi]
PST - ppublish
SO  - Surg Obes Relat Dis. 2014 Jul-Aug;10(4):641-6. doi: 10.1016/j.soard.2013.09.001. 
      Epub 2013 Sep 13.