PMID- 24239736
OWN - NLM
STAT- MEDLINE
DCOM- 20150303
LR  - 20161125
IS  - 1878-8769 (Electronic)
IS  - 1878-8750 (Linking)
VI  - 82
IP  - 3-4
DP  - 2014 Sep-Oct
TI  - Clinical usefulness of coregistered 11C-methionine positron emission 
      tomography/3-T magnetic resonance imaging at the follow-up of acromegaly.
PG  - 468-73
LID - S1878-8750(13)01431-9 [pii]
LID - 10.1016/j.wneu.2013.11.011 [doi]
AB  - OBJECTIVE: This study sought to characterize the utility of coregistered 
      11C-methionine positron emission tomography (MET-PET) with 3-T magnetic resonance 
      imaging (3T MRI) in the diagnosis and follow-up of pituitary adenomas in patients 
      with acromegaly and to compare MET-PET and 18F-fluorodeoxyglucose emission 
      tomography (FDG-PET) for the evaluation of active or recurrent disease. METHODS: 
      This is a prospective observational study. It included a total of 17 patients, 6 
      patients with a new diagnosis of acromegaly and 11 patients who had previously 
      undergone resection of a confirmed growth hormone-secreting adenoma. The study 
      protocol consisted of preoperative and postoperative evaluation with 3T MRI, and 
      both MET-PET and FDG-PET. Coregistration of 3T MRI/MET-PET was accomplished. 
      RESULTS: In all patients who underwent preoperative imaging, MET-PET demonstrated 
      increased uptake coincident with location of the pituitary lesion on 3T MRI. In 
      the postoperative group, the coregistered 3T MRI/MET-PET demonstrated evidence of 
      residual tumor in all patients with active disease. MET-PET sensitivity was 86% 
      and specificity was 86% for the diagnosis of recurrence. CONCLUSIONS: MET-PET is 
      a sensitive technique for diagnosing persistent acromegaly, and its 
      coregistration with 3T MRI has demonstrated a better definition of the interface, 
      extension, and location of the lesion in the management of active postoperative 
      acromegaly.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Rodriguez-Barcelo, Sandra
AU  - Rodriguez-Barcelo S
AD  - Department of Neurosurgery, Hospital Quiron, Murcia, Spain. Electronic address: 
      endoneurocirugia@rodriguezbarcelo.es.
FAU - Gutierrez-Cardo, Antonio
AU  - Gutierrez-Cardo A
AD  - Molecular Imaging Unit, CIMES-General Foundation of the University of Malaga, 
      Malaga, Spain.
FAU - Dominguez-Paez, Miguel
AU  - Dominguez-Paez M
AD  - Department of Neurosurgery, Carlos Haya University Hospital, Malaga, Spain.
FAU - Medina-Imbroda, Juan
AU  - Medina-Imbroda J
AD  - Department of Neurosurgery, Carlos Haya University Hospital, Malaga, Spain.
FAU - Romero-Moreno, Lorena
AU  - Romero-Moreno L
AD  - Department of Neurosurgery, Carlos Haya University Hospital, Malaga, Spain.
FAU - Arraez-Sanchez, Miguel
AU  - Arraez-Sanchez M
AD  - Department of Neurosurgery, Carlos Haya University Hospital, Malaga, Spain.
LA  - eng
PT  - Journal Article
DEP - 20131113
PL  - United States
TA  - World Neurosurg
JT  - World neurosurgery
JID - 101528275
RN  - 0 (Carbon Radioisotopes)
RN  - 0 (Radiopharmaceuticals)
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
RN  - AE28F7PNPL (Methionine)
SB  - IM
CIN - World Neurosurg. 2014 Sep-Oct;82(3-4):327-8. PMID: 24549021
CIN - World Neurosurg. 2014 Sep-Oct;82(3-4):329-30. PMID: 24631911
MH  - Acromegaly/*diagnostic imaging/pathology/*surgery
MH  - Adult
MH  - Aged
MH  - Carbon Radioisotopes
MH  - Cohort Studies
MH  - Female
MH  - Fluorodeoxyglucose F18
MH  - Follow-Up Studies
MH  - Humans
MH  - Longitudinal Studies
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - *Methionine
MH  - Middle Aged
MH  - Multimodal Imaging/*methods
MH  - Neuroimaging/*methods
MH  - Positron-Emission Tomography
MH  - *Radiopharmaceuticals
MH  - Treatment Outcome
OTO - NOTNLM
OT  - 3T MRI
OT  - Acromegaly
OT  - Methionine
OT  - PET
OT  - Pituitary adenoma
EDAT- 2013/11/19 06:00
MHDA- 2015/03/04 06:00
CRDT- 2013/11/19 06:00
PHST- 2013/04/02 00:00 [received]
PHST- 2013/10/21 00:00 [revised]
PHST- 2013/11/07 00:00 [accepted]
PHST- 2013/11/19 06:00 [entrez]
PHST- 2013/11/19 06:00 [pubmed]
PHST- 2015/03/04 06:00 [medline]
AID - S1878-8750(13)01431-9 [pii]
AID - 10.1016/j.wneu.2013.11.011 [doi]
PST - ppublish
SO  - World Neurosurg. 2014 Sep-Oct;82(3-4):468-73. doi: 10.1016/j.wneu.2013.11.011. 
      Epub 2013 Nov 13.