PMID- 24239775
OWN - NLM
STAT- MEDLINE
DCOM- 20140424
LR  - 20220311
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Print)
IS  - 0002-9394 (Linking)
VI  - 157
IP  - 3
DP  - 2014 Mar
TI  - A method to estimate the amount of neuroretinal rim tissue in glaucoma: 
      comparison with current methods for measuring rim area.
PG  - 540-9.e1-2
LID - S0002-9394(13)00729-0 [pii]
LID - 10.1016/j.ajo.2013.11.007 [doi]
AB  - PURPOSE: To test whether the minimum rim area assessed by spectral domain optical 
      coherence tomography (SD-OCT), based on the shortest distance from the Bruch 
      membrane opening (BMO) to the inner limiting membrane, corresponds more closely 
      to retinal nerve fiber layer (RNFL) thickness and visual field mean deviation 
      (MD) than current rim measures in early glaucoma. DESIGN: Prospective 
      cross-sectional study. METHODS: We studied 221 participants with non-endstage 
      glaucoma or high-risk ocular hypertension and performed standard automated 
      perimetry. We received SD-OCT and confocal scanning laser ophthalmoscopy (CSLO) 
      scans on the same day. Rim area measured by CSLO was compared with 3 SD-OCT rim 
      measures from radial B-scans: horizontal rim area between BMO and inner limiting 
      membrane within the BMO plane; mean minimum rim width (BMO-MRW); and minimum rim 
      area (BMO-MRA) optimized within sectors and then summed. Correlations between 
      these measures and either MD from perimetry or RNFL thickness from SD-OCT were 
      compared using the Steiger test. RESULTS: RNFL thickness was better correlated 
      with BMO-MRA (r = 0.676) or BMO-MRW (r = 0.680) than with either CSLO rim area (r 
      = 0.330, P < 0.001) or horizontal rim area (r = 0.482, P < 0.001). MD was better 
      correlated with BMO-MRA (r = 0.534) or BMO-MRW (r = 0.546) than with either CSLO 
      rim area (r = 0.321, P < 0.001) or horizontal rim area (0.403, P < 0.001). The 
      correlation between MD and RNFL thickness was r = 0.646. CONCLUSIONS: Minimum rim 
      measurements from SD-OCT are significantly better correlated to both RNFL 
      thickness and MD than rim measurements within the BMO plane or based on the 
      clinical disc margin. They provide new structural parameters for both diagnostic 
      and research purposes in glaucoma.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Gardiner, Stuart K
AU  - Gardiner SK
AD  - Devers Eye Institute, Legacy Research Institute, Portland, Oregon. Electronic 
      address: sgardiner@deverseye.org.
FAU - Ren, Ruojin
AU  - Ren R
AD  - Devers Eye Institute, Legacy Research Institute, Portland, Oregon; New York Eye 
      and Ear Infirmary, New York, New York.
FAU - Yang, Hongli
AU  - Yang H
AD  - Devers Eye Institute, Legacy Research Institute, Portland, Oregon.
FAU - Fortune, Brad
AU  - Fortune B
AD  - Devers Eye Institute, Legacy Research Institute, Portland, Oregon.
FAU - Burgoyne, Claude F
AU  - Burgoyne CF
AD  - Devers Eye Institute, Legacy Research Institute, Portland, Oregon.
FAU - Demirel, Shaban
AU  - Demirel S
AD  - Devers Eye Institute, Legacy Research Institute, Portland, Oregon.
LA  - eng
GR  - R01 EY019674/EY/NEI NIH HHS/United States
GR  - R01 EY021281/EY/NEI NIH HHS/United States
GR  - NIH R01-EY021281/EY/NEI NIH HHS/United States
GR  - NIH R01-EY19674/EY/NEI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20131113
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cross-Sectional Studies
MH  - *Diagnostic Techniques, Ophthalmological
MH  - Female
MH  - Glaucoma/*diagnosis
MH  - Humans
MH  - Intraocular Pressure
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/*pathology
MH  - Ophthalmoscopy
MH  - Optic Disk/*pathology
MH  - Prospective Studies
MH  - Retinal Ganglion Cells/*pathology
MH  - Tomography, Optical Coherence
MH  - Visual Field Tests
MH  - Visual Fields
PMC - PMC3944716
MID - NIHMS540854
EDAT- 2013/11/19 06:00
MHDA- 2014/04/25 06:00
PMCR- 2015/03/01
CRDT- 2013/11/19 06:00
PHST- 2013/07/11 00:00 [received]
PHST- 2013/11/05 00:00 [revised]
PHST- 2013/11/06 00:00 [accepted]
PHST- 2013/11/19 06:00 [entrez]
PHST- 2013/11/19 06:00 [pubmed]
PHST- 2014/04/25 06:00 [medline]
PHST- 2015/03/01 00:00 [pmc-release]
AID - S0002-9394(13)00729-0 [pii]
AID - 10.1016/j.ajo.2013.11.007 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2014 Mar;157(3):540-9.e1-2. doi: 10.1016/j.ajo.2013.11.007. Epub 
      2013 Nov 13.