PMID- 24242131
OWN - NLM
STAT- MEDLINE
DCOM- 20150212
LR  - 20211021
IS  - 1993-0402 (Electronic)
IS  - 1672-0415 (Linking)
VI  - 20
IP  - 6
DP  - 2014 Jun
TI  - Effects of Wenxiao Decoction on the expression of interleukin-6, intercellular 
      adhesion molecular-1 and monocyte chemoattractant protein-1 in experimental 
      atherosclerotic rabbits.
PG  - 445-9
LID - 10.1007/s11655-013-1531-6 [doi]
AB  - OBJECTIVE: To observe the effects of different doses of Wenxiao Decoction on the 
      expression of interleukin-6 (IL-6), intercellular adhesion molecule-1 (ICAM-1), 
      and monocyte chemoattractant protein-1 (MCP-1) in experimental atherosclerotic 
      rabbits and to explore the mechanism by which it alleviates atherosclerosis. 
      METHODS: Sixty New Zealand rabbits were randomly divided into six groups: a blank 
      group, a model group, a Simvastatin group, and high-, medium-, and low-dosage 
      Wenxiao Decoction groups. Except for those in the blank group, all rabbits were 
      fed with a high-cholesterol diet. Carotid atherosclerosis was established by 
      balloon-induced carotid artery endothelium injury in conjunction with the 
      high-cholesterol diet. After 8 weeks, all animals were euthanized to evaluate 
      levels of IL-6 and ICAM-1 expressions (by enzyme linked immunosorbent assay) and 
      of MCP-1 (by immunohistochemistry staining). RESULTS: The expressions of IL-6, 
      ICAM-1, and MCP-1 were significantly increased in all groups except the blank 
      group (P<0.05). However, the rabbits in the Wenxiao Decoction groups and the 
      Simvastatin group showed significantly lower levels of IL-6, ICAM-1, and MCP-1 
      expression than those in the model group (P<0.05). The expressions of IL-6, 
      ICAM-1, and MCP-1 in the highdosage Wenxiao Decoction group and the Simvastatin 
      group were lower than those in the low-dosage Wenxiao Decoction group (P<0.05). 
      The expression of MCP-1 in medium-dosage Wenxiao Decoction group was lower than 
      that in the low-dosage group (P<0.05). CONCLUSIONS: High, medium, and low doses 
      of Wenxiao Decoction can inhibit the expressions of IL-6, ICAM-1, and MCP-1, 
      which may prevent and stabilize atherosclerotic plaques. There may be a direct 
      relationship between dosage and therapeutic efficacy of Wenxiao Decoction.
FAU - Huo, Qing-ping
AU  - Huo QP
AD  - Department of Traditional Chinese Medicine, Shanghai No. 6 People's Hospital, 
      Affiliated to Shanghai Jiaotong University, Shanghai, 200233, China, 
      huoqingping005@163.com.
FAU - Liang, Fang
AU  - Liang F
FAU - Li, Jin-pu
AU  - Li JP
FAU - Wang, Yu-xin
AU  - Wang YX
FAU - Liu, Han-yan
AU  - Liu HY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131116
PL  - China
TA  - Chin J Integr Med
JT  - Chinese journal of integrative medicine
JID - 101181180
RN  - 0 (Chemokine CCL2)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Interleukin-6)
RN  - 0 (wenxiao)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
SB  - IM
MH  - Animals
MH  - Atherosclerosis/chemically induced/*metabolism/*pathology
MH  - Chemokine CCL2/*metabolism
MH  - Drugs, Chinese Herbal/*pharmacology
MH  - Immunohistochemistry
MH  - Intercellular Adhesion Molecule-1/*metabolism
MH  - Interleukin-6/*metabolism
MH  - Rabbits
EDAT- 2013/11/19 06:00
MHDA- 2015/02/13 06:00
CRDT- 2013/11/19 06:00
PHST- 2011/03/19 00:00 [received]
PHST- 2013/11/19 06:00 [entrez]
PHST- 2013/11/19 06:00 [pubmed]
PHST- 2015/02/13 06:00 [medline]
AID - 10.1007/s11655-013-1531-6 [doi]
PST - ppublish
SO  - Chin J Integr Med. 2014 Jun;20(6):445-9. doi: 10.1007/s11655-013-1531-6. Epub 
      2013 Nov 16.