PMID- 24243768
OWN - NLM
STAT- MEDLINE
DCOM- 20140304
LR  - 20140110
IS  - 1554-527X (Electronic)
IS  - 0736-0266 (Linking)
VI  - 32
IP  - 3
DP  - 2014 Mar
TI  - Efficacy of a sclerostin antibody compared to a low dose of PTH on metaphyseal 
      bone healing.
PG  - 471-6
LID - 10.1002/jor.22525 [doi]
AB  - We compared the effect of a sclerostin antibody to that of a clinically relevant 
      dose of parathyroid hormone (PTH) in a rat model for metaphyseal bone healing. 
      Screws of steel or poly methyl methacrylate (PMMA) were inserted bilaterally into 
      the proximal tibia of young male rats. During 4 weeks the animals then received 
      injections of either phosphate buffered saline (control), sclerostin antibody 
      (25 mg/kg, twice weekly) or PTH (5 microg/kg, daily). The healing response around the 
      screws was then assessed by mechanical testing and X-ray microtomography (microCT). 
      To distinguish between effects on healing and general effects on the skeleton, 
      other untraumatized bone sites and serum biomarkers were also assessed. After 4 
      weeks of treatment, PTH yielded a 48% increase in screw pull-out force compared 
      to control (p = 0.03), while the antibody had no significant effect. In contrast, 
      the antibody increased femoral cortical and vertebral strength where PTH had no 
      significant effect. microCT showed only slight changes that were statistically 
      significant for the antibody mainly at cortical sites. The results suggest that a 
      relatively low dose of PTH stimulates metaphyseal repair (screw fixation) 
      specifically, whereas the sclerostin antibody has wide-spread effects, mainly on 
      cortical bone, with less influence on metaphyseal healing.
CI  - (c) 2013 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.
FAU - Agholme, Fredrik
AU  - Agholme F
AD  - Orthopaedics, Department of Clinical and Experimental Medicine, Linkoping 
      University, Linkoping, Sweden.
FAU - Macias, Brandon
AU  - Macias B
FAU - Hamang, Matt
AU  - Hamang M
FAU - Lucchesi, Jonathan
AU  - Lucchesi J
FAU - Adrian, Mary D
AU  - Adrian MD
FAU - Kuhstoss, Stuart
AU  - Kuhstoss S
FAU - Harvey, Anita
AU  - Harvey A
FAU - Sato, Masahiko
AU  - Sato M
FAU - Aspenberg, Per
AU  - Aspenberg P
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20131114
PL  - United States
TA  - J Orthop Res
JT  - Journal of orthopaedic research : official publication of the Orthopaedic 
      Research Society
JID - 8404726
RN  - 0 (Antibodies)
RN  - 0 (Bone Density Conservation Agents)
RN  - 0 (Bone Morphogenetic Proteins)
RN  - 0 (Genetic Markers)
RN  - 0 (Sost protein, rat)
RN  - 10T9CSU89I (Teriparatide)
SB  - IM
MH  - Animals
MH  - Antibodies/*therapeutic use
MH  - Bone Density Conservation Agents/pharmacology/*therapeutic use
MH  - Bone Morphogenetic Proteins/antagonists & inhibitors/*immunology
MH  - Bone Screws
MH  - Drug Evaluation, Preclinical
MH  - Fracture Healing/*drug effects
MH  - Fractures, Bone/*drug therapy
MH  - Genetic Markers/*immunology
MH  - Male
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Teriparatide/pharmacology/*therapeutic use
OTO - NOTNLM
OT  - Wnt-signaling
OT  - bone formation
OT  - bone healing
OT  - implant fixation
OT  - mechanical testing
EDAT- 2013/11/19 06:00
MHDA- 2014/03/05 06:00
CRDT- 2013/11/19 06:00
PHST- 2012/10/19 00:00 [received]
PHST- 2013/10/25 00:00 [accepted]
PHST- 2013/11/19 06:00 [entrez]
PHST- 2013/11/19 06:00 [pubmed]
PHST- 2014/03/05 06:00 [medline]
AID - 10.1002/jor.22525 [doi]
PST - ppublish
SO  - J Orthop Res. 2014 Mar;32(3):471-6. doi: 10.1002/jor.22525. Epub 2013 Nov 14.