PMID- 24246068
OWN - NLM
STAT- MEDLINE
DCOM- 20140820
LR  - 20220321
IS  - 1940-1027 (Electronic)
IS  - 0022-2895 (Print)
IS  - 0022-2895 (Linking)
VI  - 46
IP  - 1
DP  - 2014
TI  - Individualized brain inhibition and excitation profile in response to 
      paired-pulse TMS.
PG  - 39-48
LID - 10.1080/00222895.2013.850401 [doi]
AB  - Short-interval intracortical inhibition (SICI) and intracortical facilitation 
      (ICF) are generated from paired-pulse transcranial magnetic stimulations (ppTMS) 
      using certain interstimulus intervals (ISIs). ppTMS provides an accessible 
      technique to evaluate inhibitory and facilitatory motor neural circuits. However, 
      SICI and ICF are highly variable such that individual variability is not captured 
      by any one static ISI. The authors hypothesized that individuals may have 
      individualized and relatively stable pattern of SICI-ICF profiles. They tested 
      SICI and ICF profiles using ISIs from 1 to 500 ms, on 2 occasions about 3 weeks 
      apart, and the test-retest reliability, in 23 healthy controls. Moderate-to-good 
      test-retest reliabilities were found at ppTMS with 1 and 3 ms ISIs (SICI) and 
      with 12, 15, 18, and 21 ms ISIs (ICF), but not with other control ISIs. A similar 
      pattern of results was obtained for men and women. Interestingly, the peak 
      facilitation, peak inhibition, and maximum inhibition and facilitation ranges 
      were individualized, such that they varied considerably across individuals but 
      had high repeatability within individual (Cronbach's alpha = 0.76 to 0.85). 
      Therefore, individuals appear to have unique inhibition-facilitation profiles 
      that are relatively stable. Although the functional implications of 
      individualized profiles are currently unknown, the relatively stable profiles may 
      index underlying neural inhibition and excitation traits.
FAU - Du, Xiaoming
AU  - Du X
AD  - a Maryland Psychiatric Research Center, Department of Psychiatry , University of 
      Maryland School of Medicine , Baltimore.
FAU - Summerfelt, Ann
AU  - Summerfelt A
FAU - Chiappelli, Joshua
AU  - Chiappelli J
FAU - Holcomb, Henry H
AU  - Holcomb HH
FAU - Hong, L Elliot
AU  - Hong LE
LA  - eng
GR  - MH077852/MH/NIMH NIH HHS/United States
GR  - R21 DA033817/DA/NIDA NIH HHS/United States
GR  - R01 DA027680/DA/NIDA NIH HHS/United States
GR  - T32 MH067533/MH/NIMH NIH HHS/United States
GR  - MH049826/MH/NIMH NIH HHS/United States
GR  - MH085646/MH/NIMH NIH HHS/United States
GR  - R01 MH049826/MH/NIMH NIH HHS/United States
GR  - DA027680/DA/NIDA NIH HHS/United States
GR  - R01 MH085646/MH/NIMH NIH HHS/United States
GR  - R01 MH077852/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20131118
PL  - United States
TA  - J Mot Behav
JT  - Journal of motor behavior
JID - 0236512
SB  - IM
MH  - Adult
MH  - Brain/*physiology
MH  - Cerebral Cortex/physiology
MH  - Data Interpretation, Statistical
MH  - Electromyography
MH  - Female
MH  - Humans
MH  - Individuality
MH  - Male
MH  - Middle Aged
MH  - Reproducibility of Results
MH  - Transcranial Magnetic Stimulation/*methods
PMC - PMC4038908
MID - NIHMS537514
COIS- Financial Disclosures: All authors report no conflict of interests.
EDAT- 2013/11/20 06:00
MHDA- 2014/08/21 06:00
PMCR- 2015/01/01
CRDT- 2013/11/20 06:00
PHST- 2013/11/20 06:00 [entrez]
PHST- 2013/11/20 06:00 [pubmed]
PHST- 2014/08/21 06:00 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - 10.1080/00222895.2013.850401 [doi]
PST - ppublish
SO  - J Mot Behav. 2014;46(1):39-48. doi: 10.1080/00222895.2013.850401. Epub 2013 Nov 
      18.