PMID- 24247301
OWN - NLM
STAT- MEDLINE
DCOM- 20140815
LR  - 20161128
IS  - 1423-0143 (Electronic)
IS  - 1420-4096 (Linking)
VI  - 37
IP  - 4-5
DP  - 2013
TI  - Rhabdomyolysis-induced acute kidney injury under hypoxia and deprivation of food 
      and water.
PG  - 414-21
LID - 10.1159/000350154 [doi]
AB  - BACKGROUND: To investigate the renal pathophysiologyin rhabdomyolysis-induced 
      acute kidney injury (AKI) in rats under hypoxia and deprivation of food and water 
      (HDFW), thus broadening the knowledge about rhabdomyolysis-induced AKI in massive 
      earthquake. METHODS: Male Wistar rats weighing 200-230g were randomized into 
      control, rhabdomyolysis (R), HDFW and rhabdomyolysis in combination with HDFW 
      (R/HDFW) group. Experimental rhabdomyolysis rat model was established through 
      clamping hind limb muscles, HDFW model rats were kept in 10% hypoxic chamber 
      unavailable to food and water. At 1, 3, 5, 7, 9, 11d after treatment, serum 
      creatinine (Scr) level, renal index, renal structural changes and cell apoptosis 
      were analyzed. RESULTS: After R, HDFW, R/HDFW treatment, the animals showed 
      significantly higher Scr levels than the control group. Renal index in R and 
      R/HDFW groups elevated remarkably compared with that in control and HDFW group. 
      The results of histopathology, ultra-structure and apoptosis assay suggested that 
      rhabdomyolysis caused renal tubular injury, HDFW treatment resulted in renal 
      vascular dilation, tissue congestion and tubular cell damage. In addition, more 
      severe renal lesion appeared in R/HDFW. CONCLUSIONS: We conclude that the 
      association of experimental rhabdomyolysis with HDFW results in a different 
      functional and histological pattern. The rhabdomyolysis-HDFW combination causes 
      more severe renal injury.
CI  - (c) 2013 S. Karger AG, Basel.
FAU - Wang, Jingwen
AU  - Wang J
AD  - Beijing Institute of Radiation Medicine.
FAU - Wang, Dewen
AU  - Wang D
FAU - Li, Yang
AU  - Li Y
FAU - Zuo, Hongyan
AU  - Zuo H
FAU - Wang, Shaoxia
AU  - Wang S
FAU - Xu, Xinping
AU  - Xu X
FAU - Guo, Xiaoming
AU  - Guo X
FAU - Gao, Yabing
AU  - Gao Y
FAU - Wang, Shuiming
AU  - Wang S
FAU - Peng, Ruiyun
AU  - Peng R
LA  - eng
PT  - Journal Article
DEP - 20131010
PL  - Switzerland
TA  - Kidney Blood Press Res
JT  - Kidney & blood pressure research
JID - 9610505
SB  - IM
MH  - Acute Kidney Injury/etiology/metabolism/*pathology
MH  - Animals
MH  - Food Deprivation/*physiology
MH  - Hypoxia/complications/*pathology
MH  - Male
MH  - Rats
MH  - Rats, Wistar
MH  - Rhabdomyolysis/complications/metabolism/*pathology
MH  - Water Deprivation/*physiology
EDAT- 2013/11/20 06:00
MHDA- 2014/08/16 06:00
CRDT- 2013/11/20 06:00
PHST- 2013/07/01 00:00 [accepted]
PHST- 2013/11/20 06:00 [entrez]
PHST- 2013/11/20 06:00 [pubmed]
PHST- 2014/08/16 06:00 [medline]
AID - 000350154 [pii]
AID - 10.1159/000350154 [doi]
PST - ppublish
SO  - Kidney Blood Press Res. 2013;37(4-5):414-21. doi: 10.1159/000350154. Epub 2013 
      Oct 10.