PMID- 2424776
OWN - NLM
STAT- MEDLINE
DCOM- 19860815
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 124
IP  - 1-2
DP  - 1986 May 13
TI  - Methylenedioxymethamphetamine: a potentially neurotoxic amphetamine analogue.
PG  - 175-8
AB  - The amphetamine analogue, methylenedioxymethamphetamine (MDMA) has received 
      considerable attention recently as a novel and increasingly popular psychoactive 
      agent. When administered acutely to rats in high doses, MDMA caused a selective 
      and dramatic decrease in brain concentrations of serotonin and its metabolite, 
      5-hydroxyindoleacetic acid. The depletion of serotonin and its metabolite 
      persisted for up to at least one week after a single injection of MDMA at 
      approximately four to five times the acute dose reported for humans. These 
      results are discussed in terms of the possible neurotoxic effects of MDMA.
FAU - Schmidt, C J
AU  - Schmidt CJ
FAU - Wu, L
AU  - Wu L
FAU - Lovenberg, W
AU  - Lovenberg W
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Amphetamines)
RN  - 102-32-9 (3,4-Dihydroxyphenylacetic Acid)
RN  - 333DO1RDJY (Serotonin)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - 54-16-0 (Hydroxyindoleacetic Acid)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
RN  - X77S6GMS36 (Homovanillic Acid)
SB  - IM
MH  - 3,4-Dihydroxyphenylacetic Acid/metabolism
MH  - 3,4-Methylenedioxyamphetamine/analogs & derivatives/*toxicity
MH  - Amphetamines/*toxicity
MH  - Animals
MH  - Brain/*drug effects/metabolism
MH  - Dopamine/metabolism
MH  - Homovanillic Acid/metabolism
MH  - Hydroxyindoleacetic Acid/metabolism
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Serotonin/metabolism
MH  - Time Factors
EDAT- 1986/05/13 00:00
MHDA- 1986/05/13 00:01
CRDT- 1986/05/13 00:00
PHST- 1986/05/13 00:00 [pubmed]
PHST- 1986/05/13 00:01 [medline]
PHST- 1986/05/13 00:00 [entrez]
AID - 0014-2999(86)90140-8 [pii]
AID - 10.1016/0014-2999(86)90140-8 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1986 May 13;124(1-2):175-8. doi: 10.1016/0014-2999(86)90140-8.