PMID- 24248151
OWN - NLM
STAT- MEDLINE
DCOM- 20140729
LR  - 20181202
IS  - 1791-3004 (Electronic)
IS  - 1791-2997 (Linking)
VI  - 9
IP  - 1
DP  - 2014 Jan
TI  - Cytotoxic effects of acrylonitrile on human umbilical cord mesenchymal stem cells 
      in vitro.
PG  - 97-102
LID - 10.3892/mmr.2013.1802 [doi]
AB  - The effects of acrylonitrile (ACN) on human umbilical cord mesenchymal stem cells 
      (hUC‑MSCs) remain unknown. The proliferation, differentiation, clonogenicity and 
      apoptosis effects of ACN and/or N‑acetyl‑L‑cysteine (NAC) on hUC‑MSCs were 
      investigated. The results showed that although ACN at a concentration of 
      0.1 microg/ml did not affect proliferation or the morphology of hUC‑MSCs compared 
      with the control, osteogenic differentiation and the positive rate of alkaline 
      phosphatase staining in the experimental group were significantly lower compared 
      with the control (P<0.01). All of the effects of ACN were counteracted using NAC, 
      a typical antioxidant. Using a flow cytometry assay, it was observed that ACN 
      induced apoptosis in hUC‑MSCs. The results indicated that the toxic effect 
      produced by ACN on hUC‑MSCs is based on a redox mechanism.
FAU - Sun, Xiaochun
AU  - Sun X
AD  - School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang, 
      Jiangsu 212013, P.R. China.
FAU - Sun, Min
AU  - Sun M
FAU - Xie, Yan
AU  - Xie Y
FAU - Zhai, Wei
AU  - Zhai W
FAU - Zhu, Wei
AU  - Zhu W
FAU - Ma, Rui
AU  - Ma R
FAU - Lu, Rongzhu
AU  - Lu R
FAU - Xu, Wenrong
AU  - Xu W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131115
PL  - Greece
TA  - Mol Med Rep
JT  - Molecular medicine reports
JID - 101475259
RN  - 0 (Antioxidants)
RN  - MP1U0D42PE (Acrylonitrile)
RN  - WYQ7N0BPYC (Acetylcysteine)
SB  - IM
MH  - Acetylcysteine/pharmacology
MH  - Acrylonitrile/*toxicity
MH  - Antioxidants/pharmacology
MH  - Apoptosis/drug effects
MH  - Cell Differentiation/drug effects
MH  - Cells, Cultured
MH  - Humans
MH  - Mesenchymal Stem Cells/cytology/*drug effects
MH  - Osteogenesis/drug effects
MH  - Umbilical Cord/*cytology
EDAT- 2013/11/20 06:00
MHDA- 2014/07/30 06:00
CRDT- 2013/11/20 06:00
PHST- 2013/05/09 00:00 [received]
PHST- 2013/11/05 00:00 [accepted]
PHST- 2013/11/20 06:00 [entrez]
PHST- 2013/11/20 06:00 [pubmed]
PHST- 2014/07/30 06:00 [medline]
AID - 10.3892/mmr.2013.1802 [doi]
PST - ppublish
SO  - Mol Med Rep. 2014 Jan;9(1):97-102. doi: 10.3892/mmr.2013.1802. Epub 2013 Nov 15.