PMID- 24249320
OWN - NLM
STAT- MEDLINE
DCOM- 20141022
LR  - 20211021
IS  - 1613-7671 (Electronic)
IS  - 0043-5325 (Linking)
VI  - 126
IP  - 1-2
DP  - 2014 Jan
TI  - Long-term follow-up after allogeneic stem cell transplantation in patients with 
      myelodysplastic syndromes or secondary acute myeloid leukemia: a single center 
      experience.
PG  - 23-9
LID - 10.1007/s00508-013-0449-5 [doi]
AB  - OBJECTIVE AND METHODS: We performed a single center analysis of 60 adult patients 
      (33 males and 27 females) with myelodysplastic syndromes (MDS) or secondary acute 
      myeloid leukemia (AML) who underwent allogeneic hematopoietic stem cell 
      transplantation (HCT) at our institution. RESULTS: Allogeneic stem cell in 
      patients were transplanted between 1988 and 2010, 28 had an human leukocyte 
      antigen (HLA)-identical sibling donor, 23 had an HLA-identical unrelated donor, 
      and 9 had an 1 allele mismatched donor. The median age at time of HCT was 44 
      (range: 18-68) years. Conditioning therapy was myeloablative in 36 patients and 
      consisted of a reduced-intensity conditioning (RIC) regimen in 24 patients. 
      Graft-versus-host disease (GvHD) prophylaxis was performed with a combination of 
      methotrexate and cyclosporine A in 36 patients, and cyclosporine A plus 
      mycophenolate mofetil in 24 patients. The 10-year probability of overall survival 
      was 46 %. CONCLUSION: In a multivariate analysis, we identified 
      pretransplantation serum ferritin as the only independent adverse prognostic 
      variable predicting survival in our patients.
FAU - Boehm, Alexandra
AU  - Boehm A
AD  - Department of Internal Medicine I, Bone Marrow Transplantation Unit, Medical 
      University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
FAU - Sperr, Wolfgang R
AU  - Sperr WR
FAU - Kalhs, Peter
AU  - Kalhs P
FAU - Greinix, Hildegard
AU  - Greinix H
FAU - Valent, Peter
AU  - Valent P
FAU - Worel, Nina
AU  - Worel N
FAU - Kainz, Alexander
AU  - Kainz A
FAU - Mitterbauer, Margit
AU  - Mitterbauer M
FAU - Bojic, Marija
AU  - Bojic M
FAU - Rabitsch, Werner
AU  - Rabitsch W
LA  - eng
PT  - Clinical Trial
PT  - Controlled Clinical Trial
PT  - Journal Article
DEP - 20131119
PL  - Austria
TA  - Wien Klin Wochenschr
JT  - Wiener klinische Wochenschrift
JID - 21620870R
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Anemia/diagnosis/*etiology/prevention & control
MH  - Cell Transformation, Neoplastic/drug effects/pathology
MH  - Female
MH  - Follow-Up Studies
MH  - Hematopoietic Stem Cell Transplantation/*adverse effects/*methods
MH  - Humans
MH  - Leukemia, Myeloid, Acute/*diagnosis/*surgery
MH  - Male
MH  - Middle Aged
MH  - Myelodysplastic Syndromes/*diagnosis/*surgery
MH  - Survival Analysis
MH  - Transplantation, Homologous/methods
MH  - Treatment Outcome
EDAT- 2013/11/20 06:00
MHDA- 2014/10/23 06:00
CRDT- 2013/11/20 06:00
PHST- 2013/06/19 00:00 [received]
PHST- 2013/10/14 00:00 [accepted]
PHST- 2013/11/20 06:00 [entrez]
PHST- 2013/11/20 06:00 [pubmed]
PHST- 2014/10/23 06:00 [medline]
AID - 10.1007/s00508-013-0449-5 [doi]
PST - ppublish
SO  - Wien Klin Wochenschr. 2014 Jan;126(1-2):23-9. doi: 10.1007/s00508-013-0449-5. 
      Epub 2013 Nov 19.