PMID- 24250203
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131119
LR  - 20211021
IS  - 0976-500X (Print)
IS  - 0976-5018 (Electronic)
IS  - 0976-500X (Linking)
VI  - 4
IP  - 4
DP  - 2013 Oct
TI  - Expression of cFos and brain-derived neurotrophic factor in cortex and 
      hippocampus of ethanol-withdrawn male and female rats.
PG  - 265-74
LID - 10.4103/0976-500X.119712 [doi]
AB  - OBJECTIVE: To map areas of brain activation (cFos) alongside changes in levels of 
      brain-derived neurotrophic factor (BDNF) to provide insights into neuronal 
      mechanisms contributing to previously observed sex differences in behavioral 
      measures of ethanol withdrawal (EW). MATERIALS AND METHODS: Immunohistochemical 
      analysis of cFos and BDNF levels using protein-specific antibodies and 
      visualization with nickel-enhanced DAB staining in 3 cortical and 4 hippocampal 
      regions was used to assess EW-induced expression of these proteins. RESULTS: EW 
      male and female rats showed significantly higher levels of cFos expression 
      compared to controls in the hippocampal regions whereas EW OVX rats showed higher 
      levels compared to controls only at 1 day EW in the dentate gyrus. Males 
      expressed higher basal levels of cFos in the CA1 subfield of the hippocampus and 
      in the motor cortex than either intact or OVX female rats. BDNF immunoreactivity 
      was also significantly higher in EW rats compared to that in controls, varying 
      with sex and brain region at 1 and 3 days EW. CONCLUSIONS: Sex-and brain 
      region-specific changes in expression of cFos and BDNF occurring during 1 and 
      3-day EW, suggest that differential activation and expression of neurotrophins 
      may influence the observed sex differences and support the suggestion that EW is 
      a chronic stressor, eliciting sequential neuronal activation and neurotrophin 
      regulation.
FAU - Alele, Paul E
AU  - Alele PE
AD  - Department of Biomedical and Pharmaceutical Sciences, Idaho State University, 
      Pocatello, United States of America.
FAU - Devaud, Leslie L
AU  - Devaud LL
LA  - eng
GR  - P20 RR016454/RR/NCRR NIH HHS/United States
GR  - R01 AA011877/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PL  - India
TA  - J Pharmacol Pharmacother
JT  - Journal of pharmacology & pharmacotherapeutics
JID - 101552113
PMC - PMC3826002
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - cFos
OT  - cortex
OT  - ethanol withdrawal
OT  - hippocampus
COIS- Conflict of Interest: None declared.
EDAT- 2013/11/20 06:00
MHDA- 2013/11/20 06:01
PMCR- 2013/10/01
CRDT- 2013/11/20 06:00
PHST- 2013/11/20 06:00 [entrez]
PHST- 2013/11/20 06:00 [pubmed]
PHST- 2013/11/20 06:01 [medline]
PHST- 2013/10/01 00:00 [pmc-release]
AID - JPP-4-265 [pii]
AID - 10.4103/0976-500X.119712 [doi]
PST - ppublish
SO  - J Pharmacol Pharmacother. 2013 Oct;4(4):265-74. doi: 10.4103/0976-500X.119712.