PMID- 24250383
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131119
LR  - 20211021
IS  - 1735-0328 (Print)
IS  - 1726-6890 (Electronic)
IS  - 1726-6882 (Linking)
VI  - 10
IP  - 3
DP  - 2011 Summer
TI  - The Effects of Total Flavonoids from Buckwheat Flowers and Leaves on Renal Damage 
      and PTP1B Expression in Type 2 Diabetic Rats.
PG  - 511-7
AB  - Clinical data showed consumption of buckwheat played a very positive role in the 
      relief of diabetes and its complications. The purpose of this study was to 
      explore the effects and mechanisms of the overall flavonoids from buckwheat 
      flowers and leaves (TFBFL) on renal damage in type 2 diabetes mellitus (T2DM) 
      rats. Seventy male Wistar rats were selected. Ten rats were randomly allocated 
      into a normal group and the other sixty were intragastrically injected with a 
      lipid emulsion and small doses of alloxan to induce the T2DM model. T2DM 
      inducement was judged by the fasting blood glucose (FBG) and oral glucose 
      tolerance test (OGTT). Those whose FBG was >/= 16.7 mmol/L and less tolerant to 
      glucose were considered as being T2DM rats. These rats were then randomly divided 
      into a groups termed: model (purified water, 5 mL.kg(-1) . d(-1)), BNPL (positive 
      control) (Benazepril, 4 mg.kg(-1) . d(-1)), L-TFBFL (TFBFL 100 mg.kg(-1) . 
      d(-1)), M-TFBFL (TBFL 200 mg.kg(-1) . d(-1)) and H-TFBFL (TFBFL 400 mg.kg(-1) . 
      d(-1)). Each group then received medication for a period of 4 weeks. The normal 
      rats were treated with purified water in a synchronous manner. Subsequently, FBG, 
      plasma insulin (INS), OGTT, 24 h urinary protein output, blood and urinary 
      creatinine content were assayed. Then the insulin sensitive index (ISI), 
      bilateral kidney index, and creatinine clearance rate (Ccr) were calculated. 
      Renal morphological changes and expression of protein tyrosine phosphatase 1B 
      (PTP1B) in the kidneys were observed. TFBFL lowered FBG, improved insulin 
      resistance, caused Ccr, and renal morphological changes, down-regulated the 
      expression of PTP1B in T2DM rats and showed dose-dependence. TFBFL had a 
      significant protective effect on renal damage in T2DM rats. This effect may be 
      due to lowering blood glucose and diminishing renal damage by inhibiting PTP1B 
      expression.
FAU - Chu, Jin-Xiu
AU  - Chu JX
AD  - Department of Pharmacology, North China Coal Medical University, Tangshan, China.
FAU - Wang, Zhi-Lu
AU  - Wang ZL
FAU - Han, Shu-Ying
AU  - Han SY
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Iran J Pharm Res
JT  - Iranian journal of pharmaceutical research : IJPR
JID - 101208407
PMC - PMC3813022
OTO - NOTNLM
OT  - Buckwheat
OT  - Flavonoids
OT  - PTP1B
OT  - Renal damage
OT  - Type 2 diabetes mellitus
EDAT- 2011/07/01 00:00
MHDA- 2011/07/01 00:01
PMCR- 2011/06/01
CRDT- 2013/11/20 06:00
PHST- 2013/11/20 06:00 [entrez]
PHST- 2011/07/01 00:00 [pubmed]
PHST- 2011/07/01 00:01 [medline]
PHST- 2011/06/01 00:00 [pmc-release]
AID - ijpr-10-511 [pii]
PST - ppublish
SO  - Iran J Pharm Res. 2011 Summer;10(3):511-7.