PMID- 24250954
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131119
LR  - 20211021
IS  - 2008-5117 (Print)
IS  - 2008-6830 (Electronic)
IS  - 2008-5117 (Linking)
VI  - 3
IP  - 2
DP  - 2011
TI  - The Relationship between Serum NT- Pro-BNP Levels and Prognosis in Patients with 
      Systolic Heart Failure.
PG  - 57-61
LID - 10.5681/jcvtr.2011.012 [doi]
AB  - INTRODUCTION: Most studies reported using N-terminal pro-brain natriuretic 
      peptide (NT-proBNP) in diagnosis of heart failure but there is controversy about 
      use of these tests in determining prognosis and classification of severity of 
      heart failure. The objective of this study was to determine the value of plasma 
      NT-proBNP levels assessment in evaluation of mortality and morbidity of patients 
      with systolic left ventricular dysfunction. METHODS: A cohort study was performed 
      in 150 patients with heart failure since September 2009 until February 2010. The 
      patients were followed for 6 months to assess their prognosis. Patients were 
      divided into two good and bad prognosis groups according to severity of heart 
      failure in New York Heart Association (NYHA) class and frequency of hospital 
      admission and mortality due to cardiac causes. Patients with good prognosis had 
      >/=1 admission or no mortality or NYHA class >/=2 and patients that had one of this 
      criteria considered as bad prognosis groups. Pro-BNP levels were measured at 
      baseline and left ventricular ejection fraction (LVEF) was estimated with 
      echocardiography. Data was analyzed with using Chi-square, t-test, ANOVA, 
      Kruskal-Wallis tests. RESULTS: In patients with heart failure that enrolled in 
      this clinical study, ten patients were lost during follow-up. The mean of 
      NT-proBNP is significantly correlated with ejection fraction (p=0.003) and NYHA 
      class (p<0.001). In our study among 140 patients who were follow-up for 6 months, 
      11(9.7%) of individuals died with mean NT-proBNP of 8994.8+/-8375 pg/ml, in 
      survived patients mean NT-proBNP was 3756.8+/-5645.6 pg/ml that was statistically 
      significant (P=0.02). Mean NT-proBNP in the group with good prognosis was 
      2723.8+/-4845.2 pg/ml and in the group with bad prognosis was 5420.3+/-6681 pg/ml, 
      difference was statistically significant (P=0.0001). CONCLUSION: Our study in 
      consistent with other studies confirms that NT-proBNP is significantly correlated 
      with mortality and morbidity. This could be predicting adverse out come and 
      stratification in patients with heart failure. It is recommended that more 
      research be performed in Iran.
FAU - Sokhanvar, Sepideh
AU  - Sokhanvar S
AD  - Department of Cardiology, Zanjan University of Medical Sciences, Zanjan, Iran.
FAU - Shekhi, Mahdiye
AU  - Shekhi M
FAU - Mazlomzadeh, Saeedeh
AU  - Mazlomzadeh S
FAU - Golmohammadi, Zahra
AU  - Golmohammadi Z
LA  - eng
PT  - Journal Article
DEP - 20110528
PL  - Iran
TA  - J Cardiovasc Thorac Res
JT  - Journal of cardiovascular and thoracic research
JID - 101528712
PMC - PMC3825328
OTO - NOTNLM
OT  - Heart failure
OT  - Morbidity
OT  - Mortality
OT  - Pro-BNP
OT  - Prognosis
COIS- Conflict of interests: No conflict of interest to be declared.
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
PMCR- 2011/01/01
CRDT- 2013/11/20 06:00
PHST- 2011/02/07 00:00 [received]
PHST- 2011/03/16 00:00 [accepted]
PHST- 2013/11/20 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
PHST- 2011/01/01 00:00 [pmc-release]
AID - 10.5681/jcvtr.2011.012 [doi]
PST - ppublish
SO  - J Cardiovasc Thorac Res. 2011;3(2):57-61. doi: 10.5681/jcvtr.2011.012. Epub 2011 
      May 28.