PMID- 24251997
OWN - NLM
STAT- MEDLINE
DCOM- 20150106
LR  - 20220318
IS  - 1439-7609 (Electronic)
IS  - 1439-7595 (Linking)
VI  - 24
IP  - 3
DP  - 2014 May
TI  - Clinical characteristics and medical management of Iranian patients with 
      ankylosing spondylitis.
PG  - 499-504
LID - 10.3109/14397595.2013.844302 [doi]
AB  - OBJECTIVES: Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic 
      disease with variable clinical expression. Ethnic, racial and geographical 
      factors have been associated with disease occurrence and expression. We intended 
      to describe the clinical characteristics and assess the disease severity and 
      treatment status in Iranian AS patients. METHODS: A total of 320 AS patients were 
      assessed for demographic variables, clinical manifestations, human leukocyte 
      antigen (HLA) status, disease severity, functional capacities, quality of life 
      and treatment status. RESULTS: A gender ratio of 3.8:1, an average age onset of 
      27 +/- 7.3 and a mean diagnostic delay of 8 years were observed. Eleven percent had 
      juvenile onset AS. Positive family history was higher than that observed in most 
      other countries. Enthesitis was a very common finding involving more than 
      two-thirds of our patients. Uveitis was the leading extra-articular 
      manifestation. We found an HLA-B27 prevalence of 73% and four HLA-B27 subtypes. 
      Disease activity was high and the functional status was poor as indicated by mean 
      Bath AS Disease Activity, Functional and Metrology indices. Quality of life was 
      considerably impaired in our patients. We found a low percentage of patients on 
      biological medications and a relatively higher percentage on disease modifying 
      anti-rheumatic drugs and corticosteroids. CONCLUSIONS: Our results demonstrate a 
      broad characterization of Iranian AS patients providing a better understanding of 
      this disease. A national multicenter registry would enable larger- scale 
      prospective studies to be carried out further evaluating the disease burden on 
      patients and society.
FAU - Jamshidi, Ahmad Reza
AU  - Jamshidi AR
AD  - Rheumatology Research Center, Shariati Hospital, Tehran University of Medical 
      Sciences , Tehran , Iran.
FAU - Shahlaee, Abtin
AU  - Shahlaee A
FAU - Farhadi, Elham
AU  - Farhadi E
FAU - Fallahi, Sasan
AU  - Fallahi S
FAU - Nicknam, Mohammad Hossein
AU  - Nicknam MH
FAU - Bidad, Katayoon
AU  - Bidad K
FAU - Barghamadi, Mojgan
AU  - Barghamadi M
FAU - Mahmoudi, Mahdi
AU  - Mahmoudi M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131018
PL  - England
TA  - Mod Rheumatol
JT  - Modern rheumatology
JID - 100959226
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Antirheumatic Agents)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use
MH  - Antirheumatic Agents/*therapeutic use
MH  - Female
MH  - Health Surveys
MH  - Humans
MH  - Iran
MH  - Male
MH  - Middle Aged
MH  - *Quality of Life
MH  - Severity of Illness Index
MH  - Spondylitis, Ankylosing/*diagnosis/drug therapy
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2013/11/21 06:00
MHDA- 2015/01/07 06:00
CRDT- 2013/11/21 06:00
PHST- 2013/11/21 06:00 [entrez]
PHST- 2013/11/21 06:00 [pubmed]
PHST- 2015/01/07 06:00 [medline]
AID - 10.3109/14397595.2013.844302 [doi]
PST - ppublish
SO  - Mod Rheumatol. 2014 May;24(3):499-504. doi: 10.3109/14397595.2013.844302. Epub 
      2013 Oct 18.