PMID- 24252169
OWN - NLM
STAT- MEDLINE
DCOM- 20140917
LR  - 20190318
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 155
DP  - 2014 Feb
TI  - White matter microstructure alterations of the medial forebrain bundle in 
      melancholic depression.
PG  - 186-93
LID - S0165-0327(13)00790-8 [pii]
LID - 10.1016/j.jad.2013.10.048 [doi]
AB  - BACKGROUND: The medial forebrain bundle (MFB) is a key structure of the reward 
      system and connects the ventral tegmental area (VTA) with the nucleus accumbens 
      (NAcc), the medial and lateral orbitofrontal cortex (mOFC, lOFC) and the 
      dorsolateral prefrontal cortex (dlPFC). Previous diffusion tensor imaging (DTI) 
      studies in major depressive disorder point to white matter alterations of regions 
      which may be incorporated in the MFB. Therefore, it was the aim of our study to 
      probe white matter integrity of the MFB using a DTI-based probabilistic fibre 
      tracking approach. METHODS: 22 patients with major depressive disorder (MDD) (12 
      melancholic-MDD patients, 10 non-melancholic-MDD patients) and 21 healthy 
      controls underwent DTI scans. We used a bilateral probabilistic fibre tracking 
      approach to extract pathways between the VTA and NACC, mOFC, lOFC, dlPFC 
      respectively. Mean fractional anisotropy (FA) values were used to compare 
      structural connectivity between groups. RESULTS: Mean-FA did not differ between 
      healthy controls and all MDD patients. Compared to healthy controls melancholic 
      MDD-patients had reduced mean-FA in right VTA-lOFC and VTA-dlPFC connections. 
      Furthermore, melancholic-MDD patients had lower mean-FA than non-melancholic 
      MDD-patients in the right VTA-lOFC connection. Mean-FA of these pathways 
      correlated negatively with depression scale rating scores. LIMITATIONS: Due to 
      the small sample size and heterogeneous age group comparisons between melancholic 
      and non-melancholic MDD-patients should be regarded as preliminary. CONCLUSIONS: 
      Our results suggest that the melancholic subtype of MDD is characterized by white 
      matter microstructure alterations of the MFB. White matter microstructure is 
      associated with both depression severity and anhedonia.
CI  - (c) 2013 Published by Elsevier B.V.
FAU - Bracht, Tobias
AU  - Bracht T
AD  - University Hospital of Psychiatry, University of Bern, Bolligenstrasse 111, 3000 
      Bern 60, Switzerland. Electronic address: bracht@puk.unibe.ch.
FAU - Horn, Helge
AU  - Horn H
AD  - University Hospital of Psychiatry, University of Bern, Bolligenstrasse 111, 3000 
      Bern 60, Switzerland.
FAU - Strik, Werner
AU  - Strik W
AD  - University Hospital of Psychiatry, University of Bern, Bolligenstrasse 111, 3000 
      Bern 60, Switzerland.
FAU - Federspiel, Andrea
AU  - Federspiel A
AD  - University Hospital of Psychiatry, Department of Psychiatric Neurophysiology, 
      University of Bern, Bolligenstrasse 111, 3000 Bern 60, Switzerland.
FAU - Schnell, Susanne
AU  - Schnell S
AD  - Departments of Radiology and Biomedical Engineering, Northwestern University, 
      Feinberg School of Medicine, 737 N. Michigan Ave Suite 1600, Chicago, IL 60611, 
      USA.
FAU - Hofle, Oliver
AU  - Hofle O
AD  - University Hospital of Psychiatry, University of Bern, Bolligenstrasse 111, 3000 
      Bern 60, Switzerland.
FAU - Stegmayer, Katharina
AU  - Stegmayer K
AD  - University Hospital of Psychiatry, University of Bern, Bolligenstrasse 111, 3000 
      Bern 60, Switzerland.
FAU - Wiest, Roland
AU  - Wiest R
AD  - Institute of Diagnostic and Interventional Neuroradiology, Inselspital, 
      University of Bern, Freiburgstrasse 3010, Bern, Switzerland.
FAU - Dierks, Thomas
AU  - Dierks T
AD  - University Hospital of Psychiatry, Department of Psychiatric Neurophysiology, 
      University of Bern, Bolligenstrasse 111, 3000 Bern 60, Switzerland.
FAU - Muller, Thomas J
AU  - Muller TJ
AD  - University Hospital of Psychiatry, University of Bern, Bolligenstrasse 111, 3000 
      Bern 60, Switzerland.
FAU - Walther, Sebastian
AU  - Walther S
AD  - University Hospital of Psychiatry, University of Bern, Bolligenstrasse 111, 3000 
      Bern 60, Switzerland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131105
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
SB  - IM
MH  - Adult
MH  - Anhedonia
MH  - Anisotropy
MH  - Case-Control Studies
MH  - Depressive Disorder, Major/*classification/*physiopathology
MH  - Diffusion Tensor Imaging
MH  - Female
MH  - Humans
MH  - Male
MH  - Medial Forebrain Bundle/*pathology
MH  - Middle Aged
MH  - Nerve Fibers, Myelinated/*pathology
MH  - Severity of Illness Index
OTO - NOTNLM
OT  - Anhedonia
OT  - Diffusion tensor imaging
OT  - Mood disorder
OT  - Structural imaging
EDAT- 2013/11/21 06:00
MHDA- 2014/09/18 06:00
CRDT- 2013/11/21 06:00
PHST- 2013/08/07 00:00 [received]
PHST- 2013/10/01 00:00 [revised]
PHST- 2013/10/29 00:00 [accepted]
PHST- 2013/11/21 06:00 [entrez]
PHST- 2013/11/21 06:00 [pubmed]
PHST- 2014/09/18 06:00 [medline]
AID - S0165-0327(13)00790-8 [pii]
AID - 10.1016/j.jad.2013.10.048 [doi]
PST - ppublish
SO  - J Affect Disord. 2014 Feb;155:186-93. doi: 10.1016/j.jad.2013.10.048. Epub 2013 
      Nov 5.