PMID- 24253174
OWN - NLM
STAT- MEDLINE
DCOM- 20140806
LR  - 20220330
IS  - 1435-1803 (Electronic)
IS  - 0300-8428 (Linking)
VI  - 109
IP  - 1
DP  - 2014 Jan
TI  - Coronary atherosclerosis burden, but not transient troponin elevation, predicts 
      long-term outcome in recreational marathon runners.
PG  - 391
LID - 10.1007/s00395-013-0391-8 [doi]
AB  - We determined the prognostic value of transient increases in high-sensitive serum 
      troponin I (hsTnI) during a marathon and its association with traditional 
      cardiovascular risk factors and imaging-based risk markers for incident coronary 
      events and all-cause mortality in recreational marathon runners. Baseline data of 
      108 marathon runners, 864 age-matched controls and 216 age- and risk 
      factor-matched controls from the general population were recorded and their 
      coronary event rates and all-cause mortality after 6 +/- 1 years determined. hsTnI 
      was measured in 74 marathon finishers before and after the race. Other potential 
      predictors for coronary events, i.e., Framingham Risk Score (FRS), coronary 
      artery calcium (CAC) and presence of myocardial fibrosis as measured by magnetic 
      resonance imaging-based late gadolinium enhancement (LGE), were also assessed. An 
      increase beyond the 99 % hsTnI-threshold, i.e., 0.04 mug/L, was observed in 36.5 % 
      of runners. FRS, CAC, or prevalent LGE did not predict hsTnI values above or 
      increases in hsTnI beyond the median after the race, nor did they predict future 
      events. However, runners with versus without LGE had higher hsTnI values after 
      the race (median (Q1/Q3), 0.08 mug/L (0.04/0.09) versus 0.03 mug/L (0.02/0.06), p = 
      0.039), and higher increases in hsTnI values during the race (median (Q1/Q3), 
      0.05 mug/L (0.03/0.08) versus 0.02 mug/L (0.01/0.05), p = 0.0496). Runners had a 
      similar cumulative event rate as age-matched or age- and risk factor-matched 
      controls, i.e., 6.5 versus 5.0 % or 4.6 %, respectively. Event rates in runners 
      with CAC scores <100, 100-399, and >/=400 were 1.5, 12.0, and 21.4 % (p = 0.002 for 
      trend) and not different from either control group. Runners with coronary events 
      had a higher prevalence of LGE than runners without events (57 versus 8 %, p = 
      0.003). All-cause mortality was similar in marathon runners (3/108, 2.8 %) and 
      controls (26/864, 3.0 % or 5/216, 2.4 %, respectively). Recreational marathon 
      runners with prevalent myocardial fibrosis develop higher hsTnI values during the 
      race than those without. Increasing coronary artery calcium scores and prevalent 
      myocardial fibrosis, but not increases in hsTnI are associated with higher 
      coronary event rates. All-cause mortality in marathon runners is similar to that 
      in risk factor-matched controls.
FAU - Mohlenkamp, Stefan
AU  - Mohlenkamp S
AD  - Clinic of Cardiology and Intensive Care Medicine, Bethanien Hospital Moers, 
      Bethanienstrasse 21, 47441, Moers, Germany, stefan.moehlenkamp@bethanienmoers.de.
FAU - Leineweber, Kirsten
AU  - Leineweber K
FAU - Lehmann, Nils
AU  - Lehmann N
FAU - Braun, Siegmund
AU  - Braun S
FAU - Roggenbuck, Ulla
AU  - Roggenbuck U
FAU - Perrey, Mareike
AU  - Perrey M
FAU - Broecker-Preuss, Martina
AU  - Broecker-Preuss M
FAU - Budde, Thomas
AU  - Budde T
FAU - Halle, Martin
AU  - Halle M
FAU - Mann, Klaus
AU  - Mann K
FAU - Jockel, Karl-Heinz
AU  - Jockel KH
FAU - Erbel, Raimund
AU  - Erbel R
FAU - Heusch, Gerd
AU  - Heusch G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131119
PL  - Germany
TA  - Basic Res Cardiol
JT  - Basic research in cardiology
JID - 0360342
RN  - 0 (Troponin)
SB  - IM
MH  - Aged
MH  - *Athletes
MH  - Coronary Artery Disease/*epidemiology/mortality
MH  - Female
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/epidemiology/mortality
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Risk Factors
MH  - Running
MH  - Time Factors
MH  - Troponin/*blood
EDAT- 2013/11/21 06:00
MHDA- 2014/08/07 06:00
CRDT- 2013/11/21 06:00
PHST- 2013/08/20 00:00 [received]
PHST- 2013/10/16 00:00 [accepted]
PHST- 2013/10/11 00:00 [revised]
PHST- 2013/11/21 06:00 [entrez]
PHST- 2013/11/21 06:00 [pubmed]
PHST- 2014/08/07 06:00 [medline]
AID - 10.1007/s00395-013-0391-8 [doi]
PST - ppublish
SO  - Basic Res Cardiol. 2014 Jan;109(1):391. doi: 10.1007/s00395-013-0391-8. Epub 2013 
      Nov 19.