PMID- 24253237
OWN - NLM
STAT- MEDLINE
DCOM- 20141107
LR  - 20211021
IS  - 1435-1463 (Electronic)
IS  - 0300-9564 (Linking)
VI  - 121
IP  - 4
DP  - 2014 Apr
TI  - Plasma BDNF levels are correlated with aggressiveness in patients with amnestic 
      mild cognitive impairment or Alzheimer disease.
PG  - 433-41
LID - 10.1007/s00702-013-1121-y [doi]
AB  - In the present study, we examined whether neuropsychiatric symptoms were 
      correlated with plasma brain-derived neurotrophic factor (BDNF) levels as a state 
      marker or were associated with the BDNF polymorphism Val66Met in patients with 
      amnestic mild cognitive impairment (A-MCI) or Alzheimer disease (AD). One hundred 
      and seventy-six outpatients with AD (n = 129) or A-MCI (n = 47) were selected and 
      their plasma BDNF concentrations measured. Next, we investigated the correlation 
      between the plasma BDNF level and the Behavioral Pathology in Alzheimer Disease 
      (Behave-AD) subscale scores, which reflect neuropsychiatric symptoms. We also 
      compared the plasma BDNF level and the Behave-AD subscale scores among the BDNF 
      Val66Met genotypic groups. Among the seven Behave-AD subscale scores, 
      aggressiveness was positively correlated with the plasma BDNF level (rho = 0.237, 
      P < 0.005), but did not differ significantly among the three BDNF Val66Met 
      genotypic groups. The Behave-AD total and other subscale scores did not differ 
      significantly among the BDNF Val66Met genotypic groups and were not associated 
      with the plasma BDNF level. Moreover, the plasma BDNF level did not differ 
      significantly among the three BDNF Val66Met genotypic groups or between patients 
      with A-MCI and those with AD. The plasma BDNF level was robustly correlated with 
      aggressiveness, implying that the plasma BDNF level might be useful as a 
      behavioral state marker in patients with AD or A-MCI.
FAU - Nagata, Tomoyuki
AU  - Nagata T
AD  - Department of Psychiatry, The Jikei University School of Medicine, 3-25-8 
      Nishishimbashi, Minato-ku, Tokyo, 105-8471, Japan, t.nagata@jikei.ac.jp.
FAU - Kobayashi, Nobuyuki
AU  - Kobayashi N
FAU - Shinagawa, Shunichiro
AU  - Shinagawa S
FAU - Yamada, Hisashi
AU  - Yamada H
FAU - Kondo, Kazuhiro
AU  - Kondo K
FAU - Nakayama, Kazuhiko
AU  - Nakayama K
LA  - eng
PT  - Journal Article
DEP - 20131120
PL  - Austria
TA  - J Neural Transm (Vienna)
JT  - Journal of neural transmission (Vienna, Austria : 1996)
JID - 9702341
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Aggression
MH  - Alzheimer Disease/*blood/genetics/*physiopathology
MH  - Brain-Derived Neurotrophic Factor/*blood/genetics
MH  - Cognitive Dysfunction/*blood/genetics/*physiopathology
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Methionine/genetics
MH  - Neuropsychological Tests
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Psychiatric Status Rating Scales
MH  - Statistics as Topic
MH  - Valine/genetics
EDAT- 2013/11/21 06:00
MHDA- 2014/11/08 06:00
CRDT- 2013/11/21 06:00
PHST- 2013/08/17 00:00 [received]
PHST- 2013/11/08 00:00 [accepted]
PHST- 2013/11/21 06:00 [entrez]
PHST- 2013/11/21 06:00 [pubmed]
PHST- 2014/11/08 06:00 [medline]
AID - 10.1007/s00702-013-1121-y [doi]
PST - ppublish
SO  - J Neural Transm (Vienna). 2014 Apr;121(4):433-41. doi: 10.1007/s00702-013-1121-y. 
      Epub 2013 Nov 20.