PMID- 24254997
OWN - NLM
STAT- MEDLINE
DCOM- 20150402
LR  - 20211021
IS  - 1559-0100 (Electronic)
IS  - 1355-008X (Linking)
VI  - 46
IP  - 3
DP  - 2014 Aug
TI  - Roles of thyroid hormones in follicular development in the ovary of neonatal and 
      immature rats.
PG  - 594-604
LID - 10.1007/s12020-013-0092-y [doi]
AB  - Thyroid hormones (TH) play a critical role in ovarian follicular development, 
      maturation and the maintenance of various endocrine functions. However, whether 
      TH can affect ovarian follicular development in neonatal and immature rats 
      remains unclear. Therefore, the aim of the present study was to elucidate the 
      effect of TH on ovarian follicular development in neonatal and immature rats. 
      Thirty female post-lactation mothers of Sprague-Dawley rat pups were randomly 
      divided into three groups: control, hyperthyroid (hyper), and hypothyroid (hypo). 
      On postnatal days (PND) 10 and 21, body weights, serum hormones, ovarian 
      histologic changes, and immunohistochemistry of thyroid hormone receptor alpha 1 
      (TRalpha1) and nitric oxide synthase types (NOS), and NOS activities, were 
      determined. The data showed that body weights significantly decreased in both 
      hyper and hypo groups compared with the control group (P < 0.05). In addition, 
      the hyper group had increased serum concentrations of T3, T4, and E2; whereas the 
      hypo group manifested reduced serum concentrations of T3, T4, and E2 on PND 10 
      and 21. The hyper and hypo groups showed significantly reduced total number of 
      primordial, primary and secondary follicles on PND 10 and 21 compared with the 
      control group (P < 0.05). Similarly, antral follicle numbers in the hyper and 
      hypo groups were significantly decreased on PND 21 compared with the control 
      group (P < 0.05). Immunostaining indicated that TRalpha1 and NOS were expressed in 
      ovarian surface epithelium and oocytes of growing and antral follicles, with 
      strong staining of the granulosa and theca cells of follicles. NOS activities 
      were significantly augmented in the hyper, but diminished in the hypo groups on 
      PND 10 and 21. In summary, our findings suggest that TH play important roles in 
      ovarian functions and in the regulation of NOS activity. Our results also 
      indicate that a relationship exists between the TH and NO signaling pathways 
      during the process of ovarian follicular development in neonatal and immature 
      rats.
FAU - Fedail, Jaafar Sulieman
AU  - Fedail JS
AD  - Laboratory of Animal Reproduction, College of Animal Science and Technology, 
      Nanjing Agricultural University, Nanjing, 210095, China.
FAU - Zheng, Kaizhi
AU  - Zheng K
FAU - Wei, Quanwei
AU  - Wei Q
FAU - Kong, Lingfa
AU  - Kong L
FAU - Shi, Fangxiong
AU  - Shi F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131120
PL  - United States
TA  - Endocrine
JT  - Endocrine
JID - 9434444
RN  - 0 (Thyroid Hormone Receptors alpha)
RN  - 0 (Thyroid Hormones)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Female
MH  - Hyperthyroidism/chemically induced/*metabolism
MH  - Hypothyroidism/chemically induced/*metabolism
MH  - Nitric Oxide Synthase/metabolism
MH  - Ovarian Follicle/*growth & development/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Thyroid Hormone Receptors alpha/*metabolism
MH  - Thyroid Hormones/*metabolism
EDAT- 2013/11/21 06:00
MHDA- 2015/04/04 06:00
CRDT- 2013/11/21 06:00
PHST- 2013/07/21 00:00 [received]
PHST- 2013/10/16 00:00 [accepted]
PHST- 2013/11/21 06:00 [entrez]
PHST- 2013/11/21 06:00 [pubmed]
PHST- 2015/04/04 06:00 [medline]
AID - 10.1007/s12020-013-0092-y [doi]
PST - ppublish
SO  - Endocrine. 2014 Aug;46(3):594-604. doi: 10.1007/s12020-013-0092-y. Epub 2013 Nov 
      20.