PMID- 24255779
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131122
LR  - 20211021
IS  - 2072-1439 (Print)
IS  - 2077-6624 (Electronic)
IS  - 2072-1439 (Linking)
VI  - 5
IP  - 5
DP  - 2013 Oct
TI  - High-amplitude left ventricular pacing in cardiac resynchronization therapy: an 
      alternative way to increase response rate in non-responders.
PG  - 650-7
LID - 10.3978/j.issn.2072-1439.2013.10.15 [doi]
AB  - PURPOSE: This study compared patients who underwent cardiac resynchronization 
      therapy (CRT) by high-amplitude left ventricular (LV) pacing with those who 
      underwent CRT by standard LV pacing. METHODS: We included 32 CRT patients with 
      ejection fraction (EF) </=35%, QRS time >/=120 ms, and New York Heart Association 
      (NYHA) class III/IV symptoms of heart failure despite optimal medical treatment. 
      These patients were evaluated clinically and echocardiographically before, three 
      and six months after CRT. At the 3(rd) month, the LV pulse amplitude value was 
      set high at 5 volt for 16 patients [high-amplitude Group (HAG)], while for the 
      other 16 patients, it was reduced to at least twice the threshold value at </=2.5 
      volt [low-amplitude group (LAG)]. RESULTS: Clinical and echocardiographic 
      response rates of HAG and LAG after CRT were similar in the 3(rd) and 6(th) 
      month. In both groups, increase in LVEF and decrease in LV ESV in the 3(rd) and 
      6(th) month were statistically significant compared to those before CRT, and NYHA 
      class and end-diastolic volume (EDV) was significantly reduced in the 6(th) month 
      compared to those before CRT. However, NHYA class and EDV continued to reduce 
      significantly in HAG from the 3(rd) to the 6(th) month (P<0.05), while the 
      decrease in LAG was not significant (P>0.05). The rate of mitral regurgitation 
      (MR) was reduced significantly in HAG in the 6(th) month compared to that before 
      CRT, while the decrease in LAG was not significant (P<0.05; P>0.05 respectively). 
      CONCLUSIONS: CRT by high-amplitude LV pacing was more effective according to 
      clinical and echocardiographic evaluations. It should be considered as an 
      alternative in non-responsive patients.
FAU - Zengin, Halit
AU  - Zengin H
AD  - Department of Cardiology, Faculty of Medicine, Ondokuz Mayis University, Samsun, 
      Turkey;
FAU - Akin, Filiz
AU  - Akin F
FAU - Demircan, Sabri
AU  - Demircan S
FAU - Soylu, Korhan
AU  - Soylu K
FAU - Erbay, Aliriza
AU  - Erbay A
FAU - Yuksel, Serkan
AU  - Yuksel S
FAU - Meric, Murat
AU  - Meric M
FAU - Gulel, Okan
AU  - Gulel O
FAU - Sahin, Mahmut
AU  - Sahin M
FAU - Yilmaz, Ozcan
AU  - Yilmaz O
LA  - eng
PT  - Journal Article
PL  - China
TA  - J Thorac Dis
JT  - Journal of thoracic disease
JID - 101533916
PMC - PMC3815739
OTO - NOTNLM
OT  - Heart failure (HF)
OT  - cardiac resynchronization therapy (CRT)
OT  - echocardiography
OT  - high-amplitude left ventricular pacing
EDAT- 2013/11/21 06:00
MHDA- 2013/11/21 06:01
PMCR- 2013/10/01
CRDT- 2013/11/21 06:00
PHST- 2013/10/02 00:00 [received]
PHST- 2013/10/25 00:00 [accepted]
PHST- 2013/11/21 06:00 [entrez]
PHST- 2013/11/21 06:00 [pubmed]
PHST- 2013/11/21 06:01 [medline]
PHST- 2013/10/01 00:00 [pmc-release]
AID - jtd-05-05-650 [pii]
AID - 10.3978/j.issn.2072-1439.2013.10.15 [doi]
PST - ppublish
SO  - J Thorac Dis. 2013 Oct;5(5):650-7. doi: 10.3978/j.issn.2072-1439.2013.10.15.