PMID- 24256267
OWN - NLM
STAT- MEDLINE
DCOM- 20140829
LR  - 20211021
IS  - 1470-8752 (Electronic)
IS  - 0300-5127 (Print)
IS  - 0300-5127 (Linking)
VI  - 41
IP  - 6
DP  - 2013 Dec
TI  - The links between chromatin spatial organization and biological function.
PG  - 1634-9
LID - 10.1042/BST20130213 [doi]
AB  - During the last few years, there has been a rapid increase in our knowledge of 
      how chromatin is organized inside the nucleus. Techniques such as FISH 
      (fluorescence in situ hybridization) have proved that chromosomes organize 
      themselves in so-called CTs (chromosome territories). In addition, newly 
      developed 3C (chromatin conformation capture) techniques have revealed that 
      certain chromosomal regions tend to interact with adjacent regions on either the 
      same chromosome or adjacent chromosomes, and also that regions in close proximity 
      are replicated simultaneously. Furthermore, transcriptionally repressed or active 
      areas occupy different nuclear compartments. Another new technique, named DamID 
      (DNA adenine methyltransferase identification), has strengthened the notion that 
      transcriptionally repressed genes are often found in close association with the 
      nuclear membrane, whereas transcriptionally active regions are found in the more 
      central regions of the nucleus. However, in response to various stimuli, 
      transcriptionally repressed regions are known to relocalize from the nuclear 
      lamina to the interior of the nucleus, leading to a concomitant up-regulation of 
      otherwise silenced genes. Taken together, these insights are of great interest 
      for the relationship between chromosomal spatial organization and genome 
      function. In the present article, we review recent advances in this field with a 
      focus on mammalian cells and the eukaryotic model organism Schizosaccharomyces 
      pombe.
FAU - Rodriguez, Alejandro
AU  - Rodriguez A
AD  - *Department of Medical Biochemistry and Microbiology (IMBIM), Science for Life 
      Laboratory, Uppsala University, Box 582, SE-751 23 Uppsala, Sweden.
FAU - Bjerling, Pernilla
AU  - Bjerling P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Biochem Soc Trans
JT  - Biochemical Society transactions
JID - 7506897
RN  - 0 (Chromatin)
SB  - IM
MH  - Animals
MH  - Cell Nucleus/*genetics/*metabolism
MH  - Chromatin/genetics/*metabolism
MH  - Humans
MH  - Schizosaccharomyces/cytology/*genetics/*metabolism
PMC - PMC3836414
EDAT- 2013/11/22 06:00
MHDA- 2014/08/30 06:00
PMCR- 2013/11/20
CRDT- 2013/11/22 06:00
PHST- 2013/11/22 06:00 [entrez]
PHST- 2013/11/22 06:00 [pubmed]
PHST- 2014/08/30 06:00 [medline]
PHST- 2013/11/20 00:00 [pmc-release]
AID - BST20130213 [pii]
AID - 10.1042/BST20130213 [doi]
PST - ppublish
SO  - Biochem Soc Trans. 2013 Dec;41(6):1634-9. doi: 10.1042/BST20130213.