PMID- 24257414
OWN - NLM
STAT- MEDLINE
DCOM- 20140928
LR  - 20230411
IS  - 1873-1708 (Electronic)
IS  - 0890-6238 (Linking)
VI  - 43
DP  - 2014 Jan
TI  - Indole-3-carbinol attenuates the deleterious gestational effects of bisphenol A 
      exposure on the prostate gland of male F1 rats.
PG  - 56-66
LID - S0890-6238(13)00367-5 [pii]
LID - 10.1016/j.reprotox.2013.11.001 [doi]
AB  - Bisphenol A (BPA) is a chemical that has been investigated for it potential to 
      cause prostate diseases. In this study, pregnant Sprague-Dawley rats were treated 
      with 25 or 250 mug/kg BPA from gestational day (GD) 10 to GD21 with or without 
      concurrent indole-3-carbinol (I3C) feeding. I3C is a phytochemical, and it 
      affords chemoprotection against many types of neoplasia. Male F1 rats from 
      different litters were euthanized on post-natal day (PND) 21 and PND180. 
      BPA-treated groups showed a significant increase in histopathological lesions, 
      but I3C feeding reversed many of these changes, mainly at PND180. Maternal I3C 
      feeding increased prostate epithelial apoptosis in the BPA-treated groups and 
      across age groups. Furthermore, I3C induced partial normalization of the prostate 
      histoarchitecture. The results pointed to a protective effect of maternal I3C 
      feeding during pregnancy in the BPA-exposed male offspring, thereby indicating 
      reduction in the harmful effects of gestational BPA imprinting on the prostate.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Brandt, Joyce Zalotti
AU  - Brandt JZ
AD  - Department of Morphology, Institute of Biosciences, Sao Paulo State University - 
      UNESP, Botucatu, SP 18618-970, Brazil.
FAU - Silveira, Livia Teresa R
AU  - Silveira LT
AD  - Department of Morphology, Institute of Biosciences, Sao Paulo State University - 
      UNESP, Botucatu, SP 18618-970, Brazil.
FAU - Grassi, Tony Fernando
AU  - Grassi TF
AD  - Departament of Pathology, School of Medicine - UNESP, Botucatu, SP 18618-970, 
      Brazil.
FAU - Anselmo-Franci, Janete A
AU  - Anselmo-Franci JA
AD  - Faculty of Dentistry, University of Sao Paulo - FORP/USP, Ribeirao Preto, SP 
      14040-904, Brazil.
FAU - Favaro, Wagner Jose
AU  - Favaro WJ
AD  - Institute of Biology, University of Campinas - UNICAMP, Campinas, SP 13083-862, 
      Brazil.
FAU - Felisbino, Sergio Luis
AU  - Felisbino SL
AD  - Department of Morphology, Institute of Biosciences, Sao Paulo State University - 
      UNESP, Botucatu, SP 18618-970, Brazil.
FAU - Barbisan, Luis Fernando
AU  - Barbisan LF
AD  - Department of Morphology, Institute of Biosciences, Sao Paulo State University - 
      UNESP, Botucatu, SP 18618-970, Brazil.
FAU - Scarano, Wellerson Rodrigo
AU  - Scarano WR
AD  - Department of Morphology, Institute of Biosciences, Sao Paulo State University - 
      UNESP, Botucatu, SP 18618-970, Brazil. Electronic address: scarano@ibb.unesp.br.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131117
PL  - United States
TA  - Reprod Toxicol
JT  - Reproductive toxicology (Elmsford, N.Y.)
JID - 8803591
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (Indoles)
RN  - 0 (Phenols)
RN  - 0 (Protective Agents)
RN  - 0 (Receptors, Androgen)
RN  - 0 (Receptors, Thrombin)
RN  - C11E72455F (indole-3-carbinol)
RN  - JWE1M73YZN (protease-activated receptor 4)
RN  - MLT3645I99 (bisphenol A)
SB  - IM
MH  - Animals
MH  - Apoptosis/drug effects
MH  - Benzhydryl Compounds/*toxicity
MH  - Cell Proliferation/drug effects
MH  - Endocrine Disruptors/*toxicity
MH  - Epithelial Cells/drug effects/pathology
MH  - Estrogen Receptor alpha/metabolism
MH  - Female
MH  - Indoles/*pharmacology
MH  - Male
MH  - Maternal-Fetal Exchange
MH  - Phenols/*toxicity
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*chemically induced
MH  - Prostate/*drug effects/pathology
MH  - Protective Agents/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Androgen/metabolism
MH  - Receptors, Thrombin/metabolism
OTO - NOTNLM
OT  - Bisphenol A
OT  - Chemoprevention
OT  - Indole-3-carbinol
OT  - Inflammation
OT  - Prostate
OT  - Reproductive toxicology
EDAT- 2013/11/22 06:00
MHDA- 2014/10/01 06:00
CRDT- 2013/11/22 06:00
PHST- 2013/02/27 00:00 [received]
PHST- 2013/10/04 00:00 [revised]
PHST- 2013/11/04 00:00 [accepted]
PHST- 2013/11/22 06:00 [entrez]
PHST- 2013/11/22 06:00 [pubmed]
PHST- 2014/10/01 06:00 [medline]
AID - S0890-6238(13)00367-5 [pii]
AID - 10.1016/j.reprotox.2013.11.001 [doi]
PST - ppublish
SO  - Reprod Toxicol. 2014 Jan;43:56-66. doi: 10.1016/j.reprotox.2013.11.001. Epub 2013 
      Nov 17.