PMID- 24257721 OWN - NLM STAT- MEDLINE DCOM- 20140224 LR - 20230318 IS - 1938-3207 (Electronic) IS - 0002-9165 (Print) IS - 0002-9165 (Linking) VI - 99 IP - 1 DP - 2014 Jan TI - Energy requirements in nonobese men and women: results from CALERIE. PG - 71-8 LID - 10.3945/ajcn.113.065631 [doi] AB - BACKGROUND: The energy intake necessary to maintain weight and body composition is called the energy requirement for weight maintenance and can be determined by using the doubly labeled water (DLW) method. OBJECTIVE: The objective was to determine the energy requirements of nonobese men and women in the Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy 2 study. DESIGN: Energy requirements were determined for 217 healthy, weight-stable men and women [aged >21 to <50 y; 70% female, 77% white; body mass index (BMI; in kg/m(2)) 22 to <28; 52% overweight] over 28 d with 2 consecutive 14-d DLW assessments in addition to serial measures of body weight and fat-free mass and fat mass by dual-energy X-ray absorptiometry. Energy intake and physical activity were also estimated by self-report over >/=6 consecutive d in each DLW period. RESULTS: Total daily energy expenditure (TDEE) was consistent between the 2 DLW studies (TDEE1: 2422 +/- 404 kcal/d; TDEE2: 2465 +/- 408 kcal/d; intraclass correlation coefficient = 0.90) with a mean TDEE of 2443 +/- 397 kcal/d that was, on average, 20% (580 kcal/d) higher in men than in women (P < 0.0001). The regression equation relating mean TDEE to demographics and weight was as follows: TDEE (kcal/d) = 1279 + 18.3 (weight, kg) + 2.3 (age, y) - 338 (sex: 1 = female, 0 = male); R(2) = 0.57. When body composition was included, TDEE (kcal/d) = 454 + 38.7 (fat-free mass, kg) - 5.4 (fat mass, kg) + 4.7 (age in y) + 103 (sex: 1 = female, 0 = male); R(2) = 0.65. Individuals significantly underreported energy intake (350 kcal/d; 15%), and underreporting by overweight individuals (~400 kcal/d; 16%) was greater (P < 0.001) than that of normal-weight individuals (~270 kcal/d; 12%). Estimates of TDEE from a 7-d physical activity recall and measured resting metabolic rate also suggested that individuals significantly underreported physical activity (~400 kcal/d; 17%; P < 0.0001). CONCLUSION: These new equations derived over 1 mo during weight stability can be used to estimate the free-living caloric requirements of nonobese adults. This trial was registered at clinicaltrials.gov as NCT00427193. FAU - Redman, Leanne M AU - Redman LM AD - Pennington Biomedical Research Center, Baton Rouge, LA (LMR, CKM, and ER); the Duke Clinical Research Institute and Duke University Medical Center, Durham, NC (WEK and MB); the USDA Jean Mayer Human Nutrition Research Center on Aging at Tufts University, Boston, MA (SKD and SB Roberts); the Department of Medicine, Washington University School of Medicine, St Louis, MO (SB Racette and LF); the Department of Medicine, Salerno University Medical School, Salerno, Italy (LF); CEINGE Biotecnologie Avanzate, Napoli, Italy (LF); and the USDA/Agricultural Research Service, Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX (WWW). FAU - Kraus, William E AU - Kraus WE FAU - Bhapkar, Manju AU - Bhapkar M FAU - Das, Sai Krupa AU - Das SK FAU - Racette, Susan B AU - Racette SB FAU - Martin, Corby K AU - Martin CK FAU - Fontana, Luigi AU - Fontana L FAU - Wong, William W AU - Wong WW FAU - Roberts, Susan B AU - Roberts SB FAU - Ravussin, Eric AU - Ravussin E CN - CALERIE Study Group LA - eng SI - ClinicalTrials.gov/NCT00427193 GR - U01 AG020487/AG/NIA NIH HHS/United States GR - U01AG020480/AG/NIA NIH HHS/United States GR - U01AG020487/AG/NIA NIH HHS/United States GR - U01 AG020480/AG/NIA NIH HHS/United States GR - U01 AG022132/AG/NIA NIH HHS/United States GR - P30 DK072476/DK/NIDDK NIH HHS/United States GR - P30 DK056341/DK/NIDDK NIH HHS/United States GR - U01AG020478/AG/NIA NIH HHS/United States GR - U01AG022132/AG/NIA NIH HHS/United States GR - U01 AG020478/AG/NIA NIH HHS/United States PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial PT - Research Support, N.I.H., Extramural DEP - 20131120 PL - United States TA - Am J Clin Nutr JT - The American journal of clinical nutrition JID - 0376027 SB - IM MH - Absorptiometry, Photon MH - Adult MH - Basal Metabolism MH - Body Composition MH - Body Mass Index MH - *Body Weight MH - Diet MH - *Energy Intake MH - Female MH - Humans MH - Linear Models MH - Longitudinal Studies MH - Male MH - Middle Aged MH - Motor Activity MH - *Nutritional Requirements MH - Overweight/metabolism/*prevention & control MH - Young Adult PMC - PMC3862460 EDAT- 2013/11/22 06:00 MHDA- 2014/02/25 06:00 PMCR- 2015/01/01 CRDT- 2013/11/22 06:00 PHST- 2013/11/22 06:00 [entrez] PHST- 2013/11/22 06:00 [pubmed] PHST- 2014/02/25 06:00 [medline] PHST- 2015/01/01 00:00 [pmc-release] AID - S0002-9165(23)04919-5 [pii] AID - 065631 [pii] AID - 10.3945/ajcn.113.065631 [doi] PST - ppublish SO - Am J Clin Nutr. 2014 Jan;99(1):71-8. doi: 10.3945/ajcn.113.065631. Epub 2013 Nov 20.