PMID- 24258335
OWN - NLM
STAT- MEDLINE
DCOM- 20140804
LR  - 20171116
IS  - 1520-6017 (Electronic)
IS  - 0022-3549 (Linking)
VI  - 103
IP  - 1
DP  - 2014 Jan
TI  - Mebeverine-loaded electrospun nanofibers: physicochemical characterization and 
      dissolution studies.
PG  - 283-92
LID - 10.1002/jps.23759 [doi]
AB  - Both fast dissolving and sustained release drug delivery systems (DDSs) 
      comprising mebeverine hydrochloride (MB-HCl) embedded in either povidone (PVP) 
      K60 or Eudragit((R)) L 100-55 nanofibers have been prepared by electrospinning. The 
      fibers are found to have cylindrical morphologies with smooth surfaces, except at 
      high drug loadings that appear to induce surface roughness (PVP) or fragmentation 
      (Eudragit). There is a general increase in fiber diameter with drug loading. 
      Differential scanning calorimetry and X-ray diffraction demonstrate that the drug 
      exists in an amorphous state in the fibers. Infrared spectroscopy data indicate 
      that the drug has good compatibility with the polymer, whereas nuclear magnetic 
      resonance spectroscopy and high-performance liquid chromatography analyses 
      confirmed that the MB-HCl was not degraded during the spinning process. In vitro 
      dissolution tests of the PVP fiber mats show them to dissolve within 10 s, an 
      improved dissolution profile over the pure drug. The Eudragit fibers show 
      pH-dependent drug release profiles, with only very limited release at pH 2.0 but 
      sustained release over approximately 8 h at pH 6.8. The Eudragit nanofibers have 
      the potential to be developed as oral DDSs for localized drug release in the 
      intestinal tract, whereas the PVP materials may find the application as buccal 
      delivery systems or suppositories.
CI  - (c) 2013 Wiley Periodicals, Inc. and the American Pharmacists Association.
FAU - Illangakoon, Upulitha Eranka
AU  - Illangakoon UE
AD  - School of Human Sciences, Faculty of Life Sciences and Computing, London 
      Metropolitan University, London, N7 8DB, United Kingdom; UCL School of Pharmacy, 
      University College London, London, WC1N 1AX, United Kingdom.
FAU - Nazir, Tahir
AU  - Nazir T
FAU - Williams, Gareth R
AU  - Williams GR
FAU - Chatterton, Nicholas P
AU  - Chatterton NP
LA  - eng
PT  - Journal Article
DEP - 20131120
PL  - United States
TA  - J Pharm Sci
JT  - Journal of pharmaceutical sciences
JID - 2985195R
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Phenethylamines)
RN  - 0 (Polymers)
RN  - 0 (Polymethacrylic Acids)
RN  - 25086-15-1 (methylmethacrylate-methacrylic acid copolymer)
RN  - 7F80CC3NNV (mebeverine)
RN  - FZ989GH94E (Povidone)
SB  - IM
MH  - Delayed-Action Preparations/chemistry
MH  - Drug Delivery Systems/methods
MH  - Hydrogen-Ion Concentration
MH  - Nanofibers/*chemistry
MH  - Phenethylamines/*chemistry
MH  - Polymers/chemistry
MH  - Polymethacrylic Acids/chemistry
MH  - Povidone/chemistry
MH  - Solubility
OTO - NOTNLM
OT  - Eudragit
OT  - buccal delivery
OT  - electrospun nanofibers
OT  - mebeverine hydrochloride
OT  - nanotechnology
OT  - oral drug delivery
OT  - povidone
OT  - site-specific delivery
OT  - solid dosage form
OT  - solid solutions
EDAT- 2013/11/22 06:00
MHDA- 2014/08/05 06:00
CRDT- 2013/11/22 06:00
PHST- 2013/06/14 00:00 [received]
PHST- 2013/09/26 00:00 [revised]
PHST- 2013/10/01 00:00 [accepted]
PHST- 2013/11/22 06:00 [entrez]
PHST- 2013/11/22 06:00 [pubmed]
PHST- 2014/08/05 06:00 [medline]
AID - S0022-3549(15)30746-2 [pii]
AID - 10.1002/jps.23759 [doi]
PST - ppublish
SO  - J Pharm Sci. 2014 Jan;103(1):283-92. doi: 10.1002/jps.23759. Epub 2013 Nov 20.