PMID- 24258998
OWN - NLM
STAT- MEDLINE
DCOM- 20140625
LR  - 20131122
IS  - 1940-6029 (Electronic)
IS  - 1064-3745 (Linking)
VI  - 1102
DP  - 2014
TI  - Targeting damage-associated molecular pattern molecules (DAMPs) and DAMP 
      receptors in melanoma.
PG  - 537-52
LID - 10.1007/978-1-62703-727-3_29 [doi]
AB  - Damage-associated molecular pattern molecules (DAMPs) are proteins released from 
      cells under stress due to nutrient deprivation, hypoxia, trauma, or treatment 
      with chemotherapy, among a variety of other causes. When released, DAMPs activate 
      innate immunity, providing a pathway to a systemic inflammatory response in the 
      absence of infection. By regulating inflammation in the tumor microenvironment, 
      promoting angiogenesis, and increasing autophagy with evasion of apoptosis, DAMPs 
      facilitate cancer growth. DAMPs and DAMP receptors have a key role in melanoma 
      pathogenesis. Due to their crucial role in the development of melanoma and 
      chemoresistance, DAMPs represent intriguing targets at a time when novel 
      treatments are desperately needed.
FAU - Boone, Brian A
AU  - Boone BA
AD  - Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer 
      Institute, Pittsburgh, PA, USA.
FAU - Lotze, Michael T
AU  - Lotze MT
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Methods Mol Biol
JT  - Methods in molecular biology (Clifton, N.J.)
JID - 9214969
RN  - 0 (Receptors, Pattern Recognition)
SB  - IM
MH  - Humans
MH  - Melanoma/*metabolism
MH  - Receptors, Pattern Recognition/*metabolism
MH  - Skin Neoplasms/*metabolism
EDAT- 2013/11/22 06:00
MHDA- 2014/06/26 06:00
CRDT- 2013/11/22 06:00
PHST- 2013/11/22 06:00 [entrez]
PHST- 2013/11/22 06:00 [pubmed]
PHST- 2014/06/26 06:00 [medline]
AID - 10.1007/978-1-62703-727-3_29 [doi]
PST - ppublish
SO  - Methods Mol Biol. 2014;1102:537-52. doi: 10.1007/978-1-62703-727-3_29.