PMID- 24259800
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131122
LR  - 20211021
IS  - 0915-5287 (Print)
IS  - 2187-5626 (Electronic)
IS  - 0915-5287 (Linking)
VI  - 25
IP  - 5
DP  - 2013 May
TI  - The Effects of Antecedent Exercise on Motor Function Recovery and Brain-derived 
      Neurotrophic Factor Expression after Focal Cerebral Ischemia in Rats.
PG  - 553-6
LID - 10.1589/jpts.25.553 [doi]
AB  - [Purpose] In the present study, we investigated the effect of antecedent exercise 
      on functional recovery and brain-derived neurotrophic factor (BDNF) expression 
      following focal cerebral ischemia injury. [Subjects] The rat middle cerebral 
      artery occlusion (MCAO) model was employed. Adult male Sprague-Dawley rats were 
      randomly divided into 4 groups. Group I included untreated normal rats (n=10); 
      Group II included untreated rats with focal cerebral ischemia (n=10); Group III 
      included rats that performed treadmill exercise (20 m/min) training after focal 
      cerebral ischemia (n=10); and Group IV included rats that performed antecedent 
      treadmill exercise (20 m/min) training before focal cerebral ischemia (n=10) as 
      well as treadmill exercise after ischemia. At different time points (1, 7, 14, 
      and 21 days) Garcia's score, and the hippocampal expressions level of BDNF were 
      examined. [Results] In the antecedent exercise group, improvements in the motor 
      behavior index (Garcia's score) were observed and hippocampal BDNF protein 
      expression levels increased. [Conclusion] These results indicate that antecedent 
      treadmill exercise, before permanent brain ischemia exerts a neuroprotective 
      effect against ischemia brain injury by improving motor performance and 
      increasing the level of BDNF expression. Furthermore, the antecedent treadmill 
      exercise of appropriate intensity is critical for post-stroke rehabilitation.
FAU - Kim, Gyeyeop
AU  - Kim G
AD  - Department of Physical Therapy, College of Health and Welfare, Dongshin 
      University.
FAU - Kim, Eunjung
AU  - Kim E
LA  - eng
PT  - Journal Article
DEP - 20130629
PL  - Japan
TA  - J Phys Ther Sci
JT  - Journal of physical therapy science
JID - 9105359
PMC - PMC3804980
OTO - NOTNLM
OT  - Antecedent exercise
OT  - Brain-derived neurotrophic factor
OT  - Cerebral ischemia
EDAT- 2013/11/22 06:00
MHDA- 2013/11/22 06:01
PMCR- 2013/05/01
CRDT- 2013/11/22 06:00
PHST- 2012/11/19 00:00 [received]
PHST- 2012/12/19 00:00 [accepted]
PHST- 2013/11/22 06:00 [entrez]
PHST- 2013/11/22 06:00 [pubmed]
PHST- 2013/11/22 06:01 [medline]
PHST- 2013/05/01 00:00 [pmc-release]
AID - jpts-2012-409 [pii]
AID - 10.1589/jpts.25.553 [doi]
PST - ppublish
SO  - J Phys Ther Sci. 2013 May;25(5):553-6. doi: 10.1589/jpts.25.553. Epub 2013 Jun 
      29.