PMID- 24260235
OWN - NLM
STAT- MEDLINE
DCOM- 20140711
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 8
IP  - 11
DP  - 2013
TI  - RORgammat modulates macrophage recruitment during a hydrocarbon oil-induced 
      inflammation.
PG  - e79497
LID - 10.1371/journal.pone.0079497 [doi]
LID - e79497
AB  - Hydrocarbon oils are often utilized as adjuvants in vaccines. In response to 
      naturally occurring hydrocarbon oils, inflammation is initiated and persists with 
      the continuous recruitment of immune cells such as macrophages and neutrophils. 
      However, the mechanism underlying the chronic inflammation in response to 
      hydrocarbon oils is not fully defined. In this study, we revealed an essential 
      role of retinoid-related orphan receptor gamma t (RORgammat) in sustaining the 
      recruitment of macrophages following pristane treatment. RORgammat absence resulted 
      in the incompetent formation of mesenteric oil granulomas which may associate to 
      a reduction in the migration of macrophages into the mesentery during 
      pristane-induced inflammation. This is at least partially dependent on the 
      expression of the monocyte chemoattractant protein-1 (MCP-1) in the mesentery and 
      the decrease in the macrophage reservoir in the spleen. However, the absence of 
      RORgammat had no impact on the recruitment of neutrophils to the mesentery after 
      pristane treatment. Our data uncovered an important role of RORgammat in the 
      recruitment of macrophages during hydrocarbon oil-induced chronic inflammation.
FAU - Wu, Qi
AU  - Wu Q
AD  - Tianjin Haihe Hospital, Tianjin Institute of Respiratory Diseases, Tianjin, 
      China.
FAU - Sun, Xin
AU  - Sun X
FAU - Chi, Ruo
AU  - Chi R
FAU - Xu, Long
AU  - Xu L
FAU - Li, Xue
AU  - Li X
FAU - Feng, Jing
AU  - Feng J
FAU - Chen, Huaiyong
AU  - Chen H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131115
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Ccl2 protein, mouse)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Nuclear Receptor Subfamily 1, Group F, Member 3)
RN  - 0 (Terpenes)
RN  - 26HZV48DT1 (pristane)
SB  - IM
MH  - Animals
MH  - Chemokine CCL2/genetics/metabolism
MH  - Flow Cytometry
MH  - Granuloma/chemically induced/metabolism
MH  - Inflammation/chemically induced/*metabolism
MH  - Macrophages/*cytology/*drug effects
MH  - Mesentery/immunology/metabolism/pathology
MH  - Mice
MH  - Nuclear Receptor Subfamily 1, Group F, Member 3/genetics/*metabolism
MH  - Polymerase Chain Reaction
MH  - Terpenes/pharmacology
PMC - PMC3829825
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2013/11/22 06:00
MHDA- 2014/07/12 06:00
PMCR- 2013/11/15
CRDT- 2013/11/22 06:00
PHST- 2013/08/22 00:00 [received]
PHST- 2013/10/01 00:00 [accepted]
PHST- 2013/11/22 06:00 [entrez]
PHST- 2013/11/22 06:00 [pubmed]
PHST- 2014/07/12 06:00 [medline]
PHST- 2013/11/15 00:00 [pmc-release]
AID - PONE-D-13-34337 [pii]
AID - 10.1371/journal.pone.0079497 [doi]
PST - epublish
SO  - PLoS One. 2013 Nov 15;8(11):e79497. doi: 10.1371/journal.pone.0079497. 
      eCollection 2013.