PMID- 24260316
OWN - NLM
STAT- MEDLINE
DCOM- 20140707
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 8
IP  - 11
DP  - 2013
TI  - Correlation between CT perfusion parameters and microvessel density and vascular 
      endothelial growth factor in adrenal tumors.
PG  - e79911
LID - 10.1371/journal.pone.0079911 [doi]
LID - e79911
AB  - We evaluated the correlation between computed tomography (CT) perfusion 
      parameters and markers of angiogenesis in adrenal adenomas and non-adenomas to 
      determine if perfusion CT can be used to distinguish between them. Thirty-four 
      patients with pathologically-confirmed adrenal tumors (17 adenomas, 17 
      non-adenomas) received CT perfusion imaging before surgery. CT perfusion 
      parameters (blood flow [BF], blood volume [BV], mean transit time [MTT], and 
      permeability surface area product [PS]) were calculated. Tumor tissue sections 
      were examined with immunohistochemical methods for vascular endothelial growth 
      factor (VEGF) expression and microvessel density (MVD). The mean age of the 34 
      patients was 43 years. The median BV was significantly higher in adenomas than in 
      non-adenomas [12.3 ml/100 g, inter-quartile range (IQR): 10.4 to 16.5 ml/100 g 
      vs. 8.8 ml/100 g, IQR: 3.3 to 9.4 ml/100 g, p=0.001]. Differences in BF, MTT, and 
      PS parameter values between adenomas and non-adenomas were not significant 
      (p>0.05). The mean MVD was significantly higher in adenomas compared to 
      non-adenomas (98.5 +/- 28.5 vs. 53.5 +/- 27.0, p<0.0001). Adenomas also expressed 
      significantly higher median VEGF than non-adenomas (65%, IQR: 50 to 79% vs. 45%, 
      IQR: 35 to 67%, p=0.02). A moderately strong correlation between BF and VEGF 
      (r=0.53, p=0.03) and between BV and MVD among adenomas (r=0.57, p=0.02) exist. 
      Morphology, MVD, and VEGF expression in adenomas differ significantly from 
      non-adenomas. Of the CT perfusion parameters examined, both BF and BV correlate 
      with MVD, but only BF correlates with VEGF, and only in adenomas. The significant 
      difference in BV suggests that BV may be used to differentiate adenomas from 
      non-adenomas. However, the small difference in BV shows that it may only be 
      possible to use BV to identify adenomas vs. non-adenomas at extreme BV values.
FAU - Qin, Hai-yan
AU  - Qin HY
AD  - Department of Imaging, The Fourth Affiliated Hospital, Harbin Medical University, 
      Harbin, P.R. China.
FAU - Sun, Haoran
AU  - Sun H
FAU - Wang, Xifu
AU  - Wang X
FAU - Bai, Renju
AU  - Bai R
FAU - Li, Yajun
AU  - Li Y
FAU - Zhao, Jinkun
AU  - Zhao J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131118
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Vascular Endothelial Growth Factors)
SB  - IM
MH  - Adrenal Gland Neoplasms/diagnostic imaging/*metabolism/*pathology
MH  - Adrenocortical Adenoma/diagnostic imaging/*metabolism/*pathology
MH  - Adult
MH  - Blood Volume/physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Microvessels/diagnostic imaging/metabolism/*pathology
MH  - Neovascularization, Pathologic/diagnostic imaging/metabolism/*pathology
MH  - Tomography, X-Ray Computed/methods
MH  - Vascular Endothelial Growth Factors/*metabolism
PMC - PMC3832505
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2013/11/22 06:00
MHDA- 2014/07/08 06:00
PMCR- 2013/11/18
CRDT- 2013/11/22 06:00
PHST- 2012/11/22 00:00 [received]
PHST- 2013/09/29 00:00 [accepted]
PHST- 2013/11/22 06:00 [entrez]
PHST- 2013/11/22 06:00 [pubmed]
PHST- 2014/07/08 06:00 [medline]
PHST- 2013/11/18 00:00 [pmc-release]
AID - PONE-D-12-36205 [pii]
AID - 10.1371/journal.pone.0079911 [doi]
PST - epublish
SO  - PLoS One. 2013 Nov 18;8(11):e79911. doi: 10.1371/journal.pone.0079911. 
      eCollection 2013.